Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

BioMed Research International
Hai-yang ZhaoJian Xiao

Abstract

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instable in vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factors in vivo has become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor's application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.

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Citations

Jan 28, 2017·Journal of Biomaterials Science. Polymer Edition·Jinyong Fan, Jun Yang
Oct 25, 2017·Journal of Cellular and Molecular Medicine·Yulong ZhouJian Xiao
Jul 2, 2019·The International Journal of Lower Extremity Wounds·Fahimeh RezaieHojjat Naderi-Meshkin
Apr 14, 2017·Journal of the Royal Society, Interface·Sabine van Rijt, Pamela Habibovic
Nov 7, 2019·International Journal of Molecular Sciences·Susanne Pauline RothJanina Burk
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Yizhong PengZengwu Shao
Dec 5, 2020·Regenerative Medicine·Eduardo AnituaMohammad Hamdan Alkhraisat
Apr 28, 2021·Journal of Biomedical Materials Research. Part a·María G Flores-SánchezRoberto Olayo
Oct 6, 2021·Journal of Biomaterials Applications·Nicholas J SantMartha M Murray
Nov 17, 2021·Neural Regeneration Research·Kamilla Faritovna IdrisovaRuslan Faridovich Masgutov

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Methods Mentioned

BETA
scanning electron microscopy

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