Research Imaging of Brain Structure and Function After Concussion

Headache
Catherine D Chong, Todd J Schwedt

Abstract

Even when concussions are associated with prolonged physical and cognitive sequelae, concussions are typically "invisible" on diagnostic brain imaging, indicating that the neuropathology associated with concussion lies under the detection threshold of routine imaging. However, data from brain structural and functional research imaging studies using diffusion tensor imaging, resting-state functional magnetic resonance imaging, and brain perfusion imaging indicate that these imaging sequences have a role in identifying concussion-related neuropathology. These advanced imaging techniques provide insights into concussion neuropathology and might be useful for differentiating concussed patients from healthy controls. In this review article, we provide an overview of research findings from brain structural and functional imaging studies of concussion, and discuss the accuracy of classification models developed via machine-learning algorithms for identifying individual patients with concussion based on imaging data.

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Citations

Aug 1, 2018·Current Pain and Headache Reports·Jill C RauTodd J Schwedt
Sep 7, 2018·Current Opinion in Pediatrics·Heidi K Blume
Sep 19, 2019·Nature Reviews. Neurology·Håkan AshinaDavid W Dodick
Mar 30, 2019·AJNR. American Journal of Neuroradiology·Y-C J KaoC-Y Chen
Mar 7, 2021·Current Pain and Headache Reports·Nasim MalekiX Michelle Androulakis
Mar 23, 2021·Frontiers in Behavioral Neuroscience·Taylor A McCorkleRamesh Raghupathi
Jun 22, 2021·Brain and Behavior·Joelle AmirRajeet Singh Saluja

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