PMID: 22363979Mar 1, 2012Paper

Research of endoplasmic reticulum stress and cardiovascular diseases

Sheng li ke xue jin zhan [Progress in physiology]
Yun-Yun HeChun-Lei Liu

Abstract

Endoplasmic reticulum stress is a newly discovered pathway of apoptosis, following the death receptor signaling and mitochondrial pathways. Moderate stress triggers the unfolded protein response (UPR) to rsstore the cell function. However, if the stress is severe and/or prolonged, the ER also initiates apoptotic signaling that includes CHOP, ASK1/JNK and caspases pathways. Recent studies have found that endoplasmic reticulum stress plays an important role in the development of various cardiovascular diseases. Also, extensive research has shown that it can bring about protective effects on myocardial cells through the intervention of the relevant pathways, which may provide us with new therapeutic targets for heart diseases.

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Caspases in Metabolic Diseases

Caspases, the family of cysteine proteases are involved in programmed cell death, but their role in metabolic diseases, inflammation and immunity has been of interested. Discover the latest research on caspases in metabolic diseases here.