PMID: 15374277Sep 1, 1994Paper

Research on Alzheimer's disease in Japan: a personal view on history and present status

Archives of Gerontology and Geriatrics
Y Ihara

Abstract

Research on Alzheimer's disease (AD) in Japan is briefly reviewed based mainly on our work. Paired helical filaments (PHF) have been extensively investigated for their components and phosphorylation. Their analysis has no yet provided important insights into the mechanism of neuronal death in AD brain. In beta-amyloidogenesis, the carboxyl extent of amyloid beta-protein (Abeta) is now highlighted. Abeta42, not Abeta40, is the initially deposited species. Future investigations should elucidate why Abeta42 is deposited in the brain parenchyma and how the Abeta deposition leads to PHF formation.

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Citations

May 12, 2020·Journal of Alzheimer's Disease : JAD·Claude RobertCharles-Daniel Arreto

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