Research on polyvinylidene fluoride (PVDF) hollow-fiber hemodialyzer

Biomedizinische Technik. Biomedical Engineering
Qinglei ZhangChunfeng Wu

Abstract

In this study, polyvinylidene fluoride (PVDF) hollow-fiber hemodialysis membranes were prepared by non-solvent-induced phase separation. The PVDF hollow-fiber hemodialyzers were prepared by centrifugal casting. The results showed that the PVDF membrane had better mechanical and separation properties when the membrane wall thickness was 40 μm and the N,N-dimethylacetamide in the core was 70 Vol%. Compared with commercial polysulfone hemodialysis membrane (Fresenius F60S membrane), the PVDF membrane had better mechanical property and ultrafiltration (UF) flux of pure water. The PVDF dialyzer's removal efficiency for middle molecules was proven to be much higher than that of the F60S dialyzer. The UF coefficient of a high-flux PVDF dialyzer is 62.6 ml/h/mm Hg, whereas F60S is 42.5 ml/h/mm Hg, which can promote clearance for middle molecules.

References

Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J K Leypoldt, A K Cheung
Dec 4, 2002·Artificial Organs·Kazuhiko IshiharaYasuhiko Iwasaki
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Zhongping HuangDayong Gao
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter
Jan 26, 2007·Journal of the American Society of Nephrology : JASN·Timothy W MeyerThomas H Hostetter

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Methods Mentioned

BETA
atomic force microscopy

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