PMID: 22336610Feb 18, 2012Paper

Research on serum HBV cccDNA and genotype of virus in children with chronic hepatitis B

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Yong-hong SunHong Yuan

Abstract

To study the serum HBV cccDNA and genotype of hepatitis B virus in children in Gansu province. 124 HBV-DNA positive children were randomly selected, with 84 males and 40 females. Among the 124 patients, 65 were HBV carriers, 59 were chronic hepatitis (31 mild, 18 moderate and 10 severe). Genotypes of their serum HBV, liver function, HBV-DNA load and serum HBV cccDNA were detected. In the moderate and severe groups, HBV cccDNA positive rate was higher than that in the HBV carriers or the mild group (F = 25.429, P < 0.01). The HBV cccDNA detection rate in HBeAg positive group was higher than that in the HBeAg negative group (F = 28.386, P < 0.01). In the HBV cccDNA positive group, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, total bilirubin were higher than that in the negative group (t respectively 13.241, 11.347, 15.013, P < 0.01). Both C and B genotypes appeared to be the majority while C genotype was dominant in the 124 cases of children hepatitis, with the rest as B/C and some other genotypes. The positive rate of HBV cccDNA C genotype was higher than that of the genotype B (F = 23.216, P < 0.01) and the negative rate of HBV cccDNA genotype was higher than that of the C genotype (F = 26.364, P < 0.01). H...Continue Reading

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