Research on the Balance of Thiol-Disulfide in Blood Serum in Women with Telogen Effluvium

International Journal of Trichology
Ayse AkbasOrhan Şen

Abstract

Telogen effluvium (TE) is the most common reason for hair loss in humans. Although the exact etiopathogenesis of TE has not been revealed clearly and completely, multifactorial etiologies are to be blamed. In recent years, since oxidative stress (OS) has been shown to play an important role in the etiopathogenesis of so many diseases, the effects of OS on several skin diseases are researched and analyzed. Thiols are antioxidant components that include sulfur group, and the balance of thiol-disulfide has an important role in the formation and prevention of OS. This balance is destroyed in many diseases and its effect on TE is not clearly understood yet. In this study, we aimed to search the thiol-disulfide balance that could reveal OS in patients with TE. Fifty-two patients with TE and control group of 46 persons were included in the study. Native thiol, disulfide, and total thiol levels were evaluated by a new, automatic spectrophotometric method. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol rates were calculated. There was no statistical difference between TE patients and control group in terms of native thiol, disulfide, and total thiol levels. Thiol-disulfide balance was fixed and not affected ...Continue Reading

References

Feb 1, 1961·Archives of Dermatology·A M KLIGMAN

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Citations

Feb 6, 2021·Journal of Dermatological Science·Ginny Oong Chien YinEtienne C E Wang
Dec 10, 2021·Journal of Cosmetic Dermatology·Ayşe AkbaşAkın Aktaş

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