Research Priorities in Pediatric Asthma: Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank.

The Journal of Allergy and Clinical Immunology. in Practice
Alexander G MathioudakisNikolaos G Papadopoulos

Abstract

Pediatric asthma remains a public health challenge with enormous impact worldwide. The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best tr...Continue Reading

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Citations

Jun 3, 2020·Allergy·Ioana AgacheMarek Jutel
Jul 1, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham Roberts
Aug 10, 2020·Current Opinion in Allergy and Clinical Immunology·Ioana AgacheLiliana Rogozea
Jan 22, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Nikolaos G PapadopoulosParaskevi Xepapadaki
Feb 21, 2021·Allergy·Nikolaos G PapadopoulosUNKNOWN PeARL collaborators, on behalf of the PeARL Think Tank

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