Research progress in coating techniques of alginate gel polymer for cell encapsulation

Carbohydrate Polymers
Guillermo SimóJosé Manuel Rodríguez-Nogales

Abstract

Cell encapsulation is used as a biotechnology tool to solve the technological problems derived from handling and application of cells in a great range of fields. This involves immobilization of the cells within a polymeric gel that permits the preservation of their metabolic activity. Alginate is widely established as the most suitable polymer for cell encapsulation. However, alginate gel capsules suffer several disadvantages because of their lack of mechanical and chemical stability. This review summarizes results of recent advances in coating techniques that include ionic and covalent cross-linking between alginate and coating materials for cell encapsulation as a strategy to solve the disadvantages mentioned before. Throughout this review, physicochemical properties of coated-alginate capsules and the effect of coating process on metabolic activity and viability of immobilized cells have been specially discussed.

Citations

Nov 2, 2018·International Journal of Molecular Sciences·Adejanildo da S PereiraPriscilla F F Amaral
Dec 28, 2019·Applied Microbiology and Biotechnology·Brett M Barney
May 21, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hajime KarataniMasashi Iwasaki
Oct 1, 2020·Biotechnology and Bioengineering·Mattia PasquaCécile Legallais
Feb 3, 2021·International Journal of Biological Macromolecules·Jingjing ZhuKedong Song

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