Research progress of Merlin protein and its signal pathway in tumor

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Y J Zhu, C G Shan

Abstract

Hippo signaling pathway was first found in drosophila, and was proved to participate in regulatory of cell proliferation, cell apoptosis and organ size in multicellular animals. Compared with Hippo/Mst to YAP/Yki phosphorylation of the core kinase cascade, upstream the protein interaction of Hippo kinase cascade has rarely been studied. Early studies in drosophila have shown that apical membrane associated FERM domain protein Merlin and its extension may be upstream of the Hippo pathway as a signaling pathway component. Recently, increasing researches showed that Merlin protein has a close relationship with tumor occurrence. As upstream regulatory molecule and the core in Hippo signaling pathway, the mutation or deletion of Merlin can increase oncogene Yap/Yki expression, and then contribute to tumor progression. It ultimately affects the patients' prognosis. To clarify the relationship between Merlin(NF2) and malignant tumor will be helpful for the prevention and treatment of cancer. This article revivewed the latest research progress of Merlin(NF2) protein.

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

© 2022 Meta ULC. All rights reserved