PMID: 18718104Aug 23, 2008Paper

Research Progress of microRNAs and human hematological diseases - review

Zhongguo shi yan xue ye xue za zhi
Dong-Mei Meng, Zhi-Min Miao

Abstract

The microRNAs (miRNAs) are an evolutionarily conserved class of 22 nucleotide (19 - 25 nt) non-coding RNAs. The miRNAs are partially complementary to 3' untranslated region of target mRNA, resulting in the repression of gene expression at post-transcriptional level. The miRNAs have been associated with diverse biological processes. This review summarizes recent progress of research on the characteristics and function of miRNAs, and the role of miRNAs in hematological malignancy development.

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