Research progress on the protective effects of licorice-derived 18β-glycyrrhetinic acid against liver injury.

Acta Pharmacologica Sinica
Shou-Yan WuLi-Kun Gong

Abstract

The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18β-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18β-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18β-glycyrrhetinic acid and avoid potential risks.

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Citations

Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Apr 4, 2021·International Journal of Molecular Sciences·Guifeng WangShosuke Kawanishi
May 23, 2021·Bioorganic & Medicinal Chemistry·Lidia A BaltinaCheng-Wen Lin
Jul 24, 2021·Expert Opinion on Drug Discovery·Hidayat HussainSyed Tasadaque Ali Shah
Sep 18, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Joseph William ClintonJames H Lewis

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Methods Mentioned

BETA
nuclear translocation

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