Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Randal G RossCatherine E Adams

Abstract

The onset of diagnostic symptomology for neuropsychiatric diseases is often the end result of a decades-long process of aberrant brain development. Identification of novel treatment strategies aimed at normalizing early brain development and preventing mental illness should be a major therapeutic goal. However, there are few models for how this goal might be achieved. This review uses the development of a psychophysiological correlate of attentional deficits in schizophrenia to propose a developmental model with translational primary prevention implications. Review of genetic and neurobiological studies suggests that an early interaction between alpha7 nicotinic receptor density and choline availability may contribute to the development of schizophrenia-associated attentional deficits. Therapeutic implications, including perinatal dietary choline supplementation, are discussed.

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Citations

Oct 29, 2010·Schizophrenia Bulletin·Alan S Brown, John J McGrath
Jul 25, 2015·Biochemical Pharmacology·Danielle John, Darwin K Berg
May 7, 2015·Schizophrenia Bulletin·Randal G Ross, Robert Freedman
May 1, 2015·Schizophrenia Bulletin·Larry J Seidman, Merete Nordentoft
Feb 24, 2015·Neuropharmacology·Melissa L SinkusSherry Leonard
Dec 17, 2014·Neuroscience and Biobehavioral Reviews·Monojit DebnathMichael Berk
Aug 13, 2013·NeuroImage·Kei NakagawaRyusuke Kakigi
Jul 25, 2014·The Journal of Biological Chemistry·Ying WangHenry A Lester
Oct 1, 2015·Pharmacological Reviews·Daniel BertrandDiana Donnelly-Roberts
Jul 22, 2020·Autism Research : Official Journal of the International Society for Autism Research·Hafiz M MahmoodShakir D AlSharari
May 1, 2020·Scientific Reports·Maria LavoniusMinna Huotilainen

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