Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Pamela ScorzaProgram Collaborators for Environmental influences on Child Health Outcomes

Abstract

For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to maternal prenatal distress associated with socioeconomic disadvantage compromises offspring's neurodevelopment, affecting short- and long-term physical and mental health, and thereby psychosocial standing and resources. Increasing evidence suggests that mother-to-child influence occurs prenatally, in part via maternal and offspring atypical HPA axis regulation, with negative effects on the maturation of prefrontal and subcortical neural circuits in the offspring. However, even this in utero timeframe may be insufficient to understand biological aspects of the transmission of factors contributing to disadvantage across generations. We review animal studies and emerging human research indicating that parents' childhood experiences may transfer epigenetic marks that could impact the development of their offspring independently of and in interaction with their offspring's perinatal and early childhood d...Continue Reading

References

Feb 1, 1992·Journal of Epidemiology and Community Health·D J Barker, C N Martyn
Nov 17, 1990·BMJ : British Medical Journal·D J Barker
Oct 23, 1995·Proceedings. Biological Sciences·D J Barker
Jan 19, 2000·Nature·B D Strahl, C D Allis
Aug 11, 2001·Science·T Jenuwein, C D Allis
Oct 3, 2002·Criminal Behaviour and Mental Health : CBMH·Alison E HipwellLeoniek Kroneman
Nov 25, 2003·Psychological Science·Eric TurkheimerIrving I Gottesman
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Mar 15, 2006·American Journal of Preventive Medicine·Kimberly MorlandSteve Wing
Oct 14, 2006·The Future of Children·Jens Ludwig, Susan Mayer
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea DaneseRichie Poulton
Nov 26, 2008·Paediatrics & Child Health·Hb FergusonMp Mueller
Aug 7, 2009·Human Molecular Genetics·Elmar W TobiBastiaan T Heijmans
Dec 25, 2009·The Journal of Nutrition·Hilary K SeligmanMargot B Kushel
Feb 23, 2010·Developmental Psychobiology·Frances A Champagne
Jul 1, 2010·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Kate KeenanKathleen McTigue
Aug 3, 2010·Biological Psychiatry·Tamara B FranklinIsabelle M Mansuy
Aug 3, 2010·Journal of Marriage and the Family·Rand D CongerMonica J Martin
Oct 13, 2010·Journal of Psychiatric Research·Enrique Baca-GarciaCarlos Blanco
Jun 18, 2011·Biological Psychiatry·David M DietzEric J Nestler
Aug 5, 2011·Developmental Psychobiology·Micah Leshem, Jay Schulkin
Dec 1, 2011·Nature Reviews. Neuroscience·Maurizio PopoliGerard Sanacora
Dec 6, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Gerhard DammannReinhard H Dammann
Dec 28, 2011·Pediatrics·Jack P ShonkoffUNKNOWN Section on Developmental and Behavioral Pediatrics
Feb 1, 2012·Nature Reviews. Genetics·Lucia Daxinger, Emma Whitelaw
Aug 22, 2012·Biological Psychiatry·Lorena Saavedra-Rodríguez, Larry A Feig
Oct 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Richard G HunterDonald W Pfaff
Nov 3, 2012·JAMA : the Journal of the American Medical Association·Martha L DaviglusJeremiah Stamler
Dec 12, 2012·Biological Psychiatry·Frances A Champagne
Dec 22, 2012·Nature Neuroscience·Moshe Szyf
Mar 2, 2013·The International Journal of Neuropsychopharmacology·Philippe A MelasCatharina Lavebratt

❮ Previous
Next ❯

Citations

Feb 24, 2019·Annual Review of Clinical Psychology·Catherine MonkCaroline Trumpff
Dec 10, 2019·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Darcia Narvaez, Laura Duckett
Feb 25, 2019·Archives of Disease in Childhood·Anna PearceDavid Taylor-Robinson
Aug 3, 2019·Developmental Psychobiology·Maria C J van de VenMoriah E Thomason
May 10, 2020·Journal of Racial and Ethnic Health Disparities·Kirsten A RigganMegan A Allyse
Dec 22, 2020·The American Journal of Bioethics : AJOB·Maya SabatelloGwen Darien
Aug 22, 2020·Developmental Cognitive Neuroscience·Susan BranjeDorret I Boomsma
Aug 2, 2021·Developmental Psychobiology·Sarah M MerrillNicole L Letourneau
Nov 14, 2021·Prevention Science : the Official Journal of the Society for Prevention Research·Neda SenehiMichelle Sarche

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.