Research Review: The strength of the genetic overlap between ADHD and other psychiatric symptoms - a systematic review and meta-analysis.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Anneli AnderssonHenrik Larsson

Abstract

Attention-deficit/hyperactivity disorder (ADHD) frequently co-occurs with other psychiatric disorders. Twin studies have established that these co-occurrences are in part due to shared genetic risks. However, the strength of these genetic overlaps and the potential heterogeneity accounted for by type of psychiatric symptoms, age, and methods of assessment remain unclear. We conducted a systematic review to fill this gap. We searched PubMed, PsycINFO, Embase, and Web of Science until March 07, 2019. Genetic correlations (rg ) were used as effect size measures. A total of 31 independent studies fulfilled the inclusion criteria. The pooled estimates showed that the associations between ADHD and other psychiatric symptoms were partly explained by shared genetic factors, with a pooled genetic correlation of 0.50, 95% confidence interval: 0.46-0.60. The genetic correlations (rg ) between ADHD and externalizing (rg  = .49 [0.37-0.61]), internalizing (rg  = .50 [0.39-0.69]), and neurodevelopmental (rg  = .56 [0.47-0.66]) symptoms were similar in magnitude. The genetic correlations in childhood and adulthood were rg  = .53 (0.43-0.63) and rg  = .51 (0.44-0.56), respectively. For methods of assessment, the genetic correlations were also ...Continue Reading

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Citations

Aug 29, 2020·Current Opinion in Psychiatry·Andrea Raballo, Michele Poletti
Apr 6, 2021·Psychological Medicine·Isabell BrikellJoanna Martin
May 23, 2021·Neuroscience and Biobehavioral Reviews·Samantha L ReganCharles V Vorhees

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