PMID: 45298Jul 1, 1979

Researches on some properties of inhibitory substances produced by strains of "N. meningitidis" (author's transl)

Annali Sclavo; rivista di microbiologia e di immunologia
S BarbutiM T Montagna

Abstract

Some properties of three inhibitory substances produced by as many strains of N. meningitidis have been studied. All these substances appeared to be completely destroyed by proteolytic enzymes (trypsin and pronase) and to be very heat-stable; they were insensitive to ultraviolet light and they were stable pH 2-10; filtration through filters of different porosity (Seitz, Berkefeld, millipore membranes) resulted in loss of the inhibitory effect constantly. On the basis of these results and on their specific action specific action, it is possible to class these substances among bacteriocins ("meningocins") at low molecular weight.

Related Concepts

Neisseria meningitidis
Bacteriocin
Tissue Membrane
Filtration
Peptide Hydrolases
Proteolytic enzymes for treatment of wounds and ulcers
Trypsin
Lantibiotics
Pronase
Hydrogen-Ion Concentration

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