Resectability After First-Line FOLFIRINOX in Initially Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Experience

Annals of Surgical Oncology
Ulrich NitscheJörg Kleeff

Abstract

FOLFIRINOX is an active but relatively toxic chemotherapeutic regimen for patients with metastatic pancreatic ductal adenocarcinoma (PDAC). The increased frequency of responding tumors shift interest to neoadjuvant approaches. We report our institutional experience with FOLFIRINOX for therapy-naïve patients with locally advanced and initially unresectable PDAC. All patients with unresectable locally advanced PDAC who underwent treatment with FOLFIRINOX at a single center between 2011 and 2014 were identified and evaluated retrospectively regarding chemotherapy response, toxicity, conversion to resectability, and survival. Resectability, response to chemotherapy, and postoperative complications were reported according to NCCN-guidelines, RECIST-criteria, and Clavien-Dindo-classification, respectively. Overall, 14 patients received FOLFIRINOX as first-line therapy for locally advanced and unresectable PDAC. Fifty-seven percent of the patients had severe tumor-related comorbidities at the time of diagnosis, and in 86 %, dose reduction due to toxicity was necessary during a median of seven cycles. Nevertheless, only one patient had progressive disease during FOLFIRINOX, whereas the others experienced stable disease (n = 6) or parti...Continue Reading

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Mar 21, 2008·Annals of Surgical Oncology·Irene EspositoMarkus W Büchler
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 1, 2010·British Journal of Cancer·N ZaniniE Jovine
Jul 3, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K L PrenzelD L Stippel
Sep 9, 2010·JAMA : the Journal of the American Medical Association·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
May 31, 2011·Lancet·Audrey VincentMichael Goggins
Jun 9, 2012·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoUNKNOWN National Comprehensive Cancer Networks
Aug 21, 2013·Journal of Surgical Oncology·Brian A BooneNathan Bahary
Dec 18, 2013·Zeitschrift für Gastroenterologie·T SeufferleinE Yekebas
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 27, 2014·The Oncologist·Kathleen K ChristiansBen George
May 27, 2014·Surgery·Maximilian BockhornUNKNOWN International Study Group of Pancreatic Surgery
Aug 8, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoDeborah A Freedman-Cass
Oct 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·S ValeriR Coppola
Apr 15, 2015·Pancreas·Fausto PetrelliUNKNOWN Gruppo Italiano per lo Studio dei Carcinomi dell’Apparato Digerente (GISCAD)

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Citations

Mar 13, 2016·Cancer Letters·Thilo HackertMarkus W Büchler
May 4, 2016·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J KleeffW T Knoefel
Apr 3, 2016·International Journal of Cancer. Journal International Du Cancer·Caterina VivaldiEnrico Vasile
May 18, 2017·Journal of Surgical Oncology·Jad Abou-Khalil, Flavio G Rocha
Aug 31, 2017·Current Treatment Options in Gastroenterology·Laura Maggino, Charles M Vollmer
May 10, 2016·Nature Reviews. Disease Primers·Jorg KleeffJohn P Neoptolemos
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Andrew L CovelerE Gabriela Chiorean
May 3, 2018·Nature Reviews. Gastroenterology & Hepatology·John P NeoptolemosDaniel H Palmer
Apr 14, 2018·Journal of Hepato-biliary-pancreatic Sciences·Junji FuruseMasanori Sugiyama
Jun 22, 2019·Annals of Hepato-biliary-pancreatic Surgery·Kyriaki LekkaDimitrios Giakoustidis
Nov 14, 2019·Journal of Clinical Medicine·Thomas Hank, Oliver Strobel
Sep 12, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R FietkauD Lubgan
Apr 16, 2020·World Journal of Surgery·Nobuhiro TsuchiyaItaru Endo
Jul 22, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shohei YoshiyaMasaki Mori
Jan 4, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Stacey KirkpatrickSteven J Hughes
Nov 9, 2021·Future Oncology·Monish Karunakaran, Savio George Barreto

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