PMID: 11906415Mar 22, 2002Paper

Resecting large numbers of hepatic colorectal metastases

ANZ Journal of Surgery
Paul MorozBruce N Gray

Abstract

Despite the widespread use of surgical resection as a treatment for hepatic colorectal metastases, the value of resecting more than three metastases remains controversial. It was the objective of this study to determine if resection of larger numbers of metastases affects patient survival. The survival of 123 consecutive patients who underwent curative hepatic resection for colorectal metastases between 1989 and 1999 by a single surgeon was analysed retrospectively. Kaplan-Meier survival statistics and Cox regression were used to determine the factors that affected survival, and logistic regression was used to determine the factors that affected the risk of recurrence of hepatic disease. The median survival rate for the whole group of patients was 38 months, with 1, 3 and 5 year survival rates of 88%, 53% and 31% respectively. The survival rate of patients undergoing resection of four to seven metastases (n=22; 5 year survival=39%) was not significantly different to that of patients undergoing resection of one to three metastases (n=91; 5 year survival=30%), P=0.9. Age, sex, primary cancer site, hepatic disease distribution, resection margins and adjuvant hepatic arterial chemotherapy (HAC) did not affect survival. Local invasi...Continue Reading

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Citations

Apr 27, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David M CashWilliam C Chapman
Mar 22, 2002·ANZ Journal of Surgery·David L Morris
Feb 22, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N ChafaiP H Chapuis
Jan 14, 2005·Gut·M J SchindlUNKNOWN Edinburgh Liver Surgery and Transplantation Experimental Research Group (eLISTER)
Nov 15, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L SpeltR Andersson
Aug 27, 2005·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·A J BrooksD L Morris
Nov 5, 2003·The British Journal of Surgery·R J KennedyG Farshid

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