PMID: 8965593Jan 1, 1996Paper

Resection of liver metastases of colorectal tumors. A uni- and multivariate analysis of prognostic factors

Langenbecks Archiv für Chirurgie
J K Seifert, T Junginger

Abstract

Between September 1985 and December 1994, liver resections with curative intent were performed for liver metastases of colorectal primaries in 76 patients at the department for abdominal surgery of the university of Mainz. Perioperative morbidity and 30-day mortality rates were 30.3% and 6.6% respectively. The 3- and 5-year survival rate was 53% and 36% respectively. For patients with complete tumor removal (R0 resection), excluding perioperative mortality, the following factors were associated with more prolonged survival after hepatic resection in univariate analysis. N1 stage of the colorectal primary compared to N2 stage (in patients with positive mesenterial lymph nodes); diameter of the largest metastasis between 2.1 and 3.5 cm; postoperative normalized CEA level (in patients with CEA level elevated to more than 4 ng/dl preoperatively); and wedge resections compared to hemihepatectomies. Regarding disease-free survival, only N1 stage of the colorectal primary compared to N2 stage and diameter of the largest metastasis between 2.1 and 3.5 cm had a positive influence. In multivariate analysis, the diameter of the largest metastasis was the only factor associated with survival time, while disease-free survival was influenced...Continue Reading

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Citations

Oct 13, 1998·The Australian and New Zealand Journal of Surgery·J K Seifert, D L Morris
Aug 26, 1998·Annals of Surgery·J K Seifert, D L Morris
Jun 24, 2005·International Journal of Colorectal Disease·Joachim K SeifertTheodor Junginger
Apr 22, 1999·Diseases of the Colon and Rectum·J K Seifert, D L Morris
Apr 3, 2004·Technology in Cancer Research & Treatment·J K Seifert, T Junginger
Apr 1, 1999·The British Journal of Surgery·J K Seifert, D L Morris

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