Resection strategies for adrenocortical carcinoma

Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
S Schimmack, O Strobel

Abstract

Adrenocortical carcinomas (ACC) are rare and aggressive neoplasms. Due to their high rate of local recurrence and distant metastases (up to 85%) they are associated with a poor survival. The 5‑year survival in ACC patients with lymph node metastasis or local infiltration is 50% and with distant metastasis less than 15%. An R0 resection with locoregional and para-aortic/paracaval lymphadenectomy is the only curative option and reasonable treatment possibility. The treatment of these patients should therefore be planned and carried out in centers. Local recurrences and distant metastases should also be treated with R0 resection when feasible, combined with neoadjuvant/adjuvant chemotherapy and/or radiation. In the case of an asymptomatic non-resectable ACC, debulking operations cannot be recommended. The primary operation can also be done in a minimally invasive procedure if principles of oncological surgery are followed (radical resection, no damage of the tumor capsule, lymphadenectomy), since survival after open and minimally invasive laparoscopic resection was comparable. Palliative resections are only indicated in symptomatic patients.

References

May 18, 2001·Archives of Surgery·M L KendrickJ A van Heerden
Sep 26, 2001·Cancer·R Vassilopoulou-Sellin, P N Schultz
Sep 27, 2001·World Journal of Surgery·A P DackiwD B Evans
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander StojadinovicMurray F Brennan
Dec 20, 2005·Surgery·Ricardo J GonzalezJeffrey E Lee
Mar 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Bruno Allolio, Martin Fassnacht
May 9, 2006·World Journal of Surgery·Electron KebebewAlex McMillan
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtBruno Allolio
Mar 28, 2007·Surgery Today·Susumu OhwadaMasanobu Yamada
Jun 9, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Martin Fassnacht, Bruno Allolio
Jun 29, 2010·European Urology·David BrixUNKNOWN German Adrenocortical Carcinoma Registry Group
Jul 30, 2010·The Journal of Clinical Endocrinology and Metabolism·Martin FassnachtUNKNOWN German ACC Registry Group
Oct 1, 2011·The Annals of Thoracic Surgery·Clinton D KempDavid S Schrump
Nov 10, 2011·Langenbeck's Archives of Surgery·Celestino Pio LombardiRocco Bellantone
Dec 7, 2011·Annals of Surgery·Joachim ReibetanzUNKNOWN German ACC study group
Dec 23, 2011·Journal of Surgical Oncology·Nicole M DatriceItzhak Avital
Apr 25, 2012·Annals of Surgical Oncology·Sébastien GaujouxWilliam R Jarnagin
Jun 19, 2012·Surgery·Ilse G C HermsenUNKNOWN Dutch Adrenal Network
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BerrutiUNKNOWN ESMO Guidelines Working Group
Nov 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Ilknur ErdoganUNKNOWN German Adrenocortical Carcinoma Study Group
Apr 4, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Isabelle BourdeauAndré Lacroix
May 4, 2013·European Journal of Endocrinology·T M A KerkhofsUNKNOWN Dutch Adrenal Network
Oct 3, 2013·European Journal of Endocrinology·Montserrat Ayala-RamirezMouhammed Amir Habra
Nov 14, 2013·Molecular and Cellular Endocrinology·Antonio M LerarioGary D Hammer
Nov 19, 2013·Surgery·Benzon M DyGeoffrey B Thompson
Aug 6, 2014·Annals of Surgical Oncology·Benzon M DyGeoffrey B Thompson
Jan 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Felix BeuschleinMartin Fassnacht
May 6, 2015·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N SaadeM Goldfarb
Aug 19, 2015·Annals of Surgical Oncology·Neda AminiTimothy M Pawlik
Sep 4, 2016·Annals of Surgical Oncology·Jon M GerryGeorge A Poultsides
Nov 22, 2016·Surgery·Danuel V LaanTravis J McKenzie

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Citations

Apr 17, 2019·Molecular and Cellular Biochemistry·Xueyi WuLizhi Wang
Jul 17, 2020·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S SchimmackO Strobel

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