Resective surgery in infants and young children with intractable epilepsy

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Richard G BittarA S Harvey

Abstract

Despite the relatively high incidence of epilepsy during the first few years of life, and its documented adverse impact on development, few studies have documented the long term outcomes following epilepsy surgery in infants and young children. We report a consecutive series of 11 patients under 3 years of age who underwent excisional surgery for intractable seizures. A total of 16 resective procedures were performed, and comprised functional hemispherectomy, temporal lobectomy, and lesionectomy. The mean follow-up period was 3 years. At follow-up, 73% (8/11) were seizure-free, with over half of these patients able to cease anti-epileptic medications. Acceleration of neurodevelopment was seen in all patients in whom preoperative developmental delay was present. Quality of life was enhanced in all patients. This series confirms that excellent results can be obtained following excisional surgery in well-selected infants and young children with intractable seizures.

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Citations

Mar 3, 2012·Journal of Neurosurgery. Pediatrics·Massimo CossuGiorgio Lo Russo
Jun 3, 2011·Journal of Neurosurgery. Pediatrics·Ahmad R MohamedA Simon Harvey
Jul 14, 2012·Neural Plasticity·Mark W BurkeMaurice Ptito
Jan 31, 2006·Neurologic Clinics·Robert W Hickey, Michael J Painter
Jan 30, 2009·Epilepsia·Paul SteinbokJeffrey Atkinson
May 9, 2007·Epilepsia·Floor E JansenOnno van Nieuwenhuizen
Jul 25, 2007·Epilepsia·Massimo CossuFrancesco Cardinale
Aug 24, 2005·Seminars in Pediatric Neurology·Deepak K Lachhwani
May 30, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramesh M KumarBrent R O'Neill
Jul 29, 2015·Seizure : the Journal of the British Epilepsy Association·Jesper ReinholdsonKristina Malmgren
Sep 18, 2012·Epilepsy & Behavior : E&B·Gerd ViggedalPaul Uvebrant
Apr 30, 2016·Journal of Neurosurgery. Pediatrics·Benoit JennyKarl Schaller
Dec 9, 2017·Wiener klinische Wochenschrift·Gudrun GröppelMartha Feucht
Jun 21, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M CossuG Lo Russo
Jul 6, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C Di RoccoL Massimi
Mar 3, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Cecília Souza-OliveiraAmérico Ceiki Sakamoto
Apr 2, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Romina MoaveroPaolo Curatolo
Jul 22, 2018·Journal of Neurosurgery. Pediatrics·Hannah E GoldsteinNeil A Feldstein
May 16, 2019·Journal of Korean Neurosurgical Society·Samuel B TomlinsonBenjamin C Kennedy
Apr 13, 2021·Neurology. Clinical Practice·Karen LidzbaMartin Staudt
Sep 19, 2020·Journal of Neurosurgery. Pediatrics·Rafael Uribe-CardenasCaitlin E Hoffman

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