PMID: 6976794Nov 1, 1981Paper

Resemblance between rhodopsin kinase and S-antigen induced uveitis

The British Journal of Ophthalmology
R B NussenblattI Gery

Abstract

The retinal S-antigen (S-Ag) has been shown to induce uveitis effectively in subhuman primates, and lymphocytes from patients with certain uveitic conditions show cell-mediated responses to this antigen. Rhodopsin kinase (RK), an enzyme probably unique to the mammalian eye, is reported here to resemble the retinal S-Ag in its capacity to induce uveitis in experimental animals. A histological comparison of rat eyes taken 2 and 3 weeks after immunisation with either RK or S-Ag reveals essentially identical pathological alterations. Ocular inflammation is seen in both the anterior and posterior portion of the globe. Areas of focal degeneration of the photo-receptor layer, from which both the S-Ag and RK are extracted, could be seen in both RK and S-Ag immunised animals. Cells from draining lymph nodes of both groups responded by increased thymidine incorporation when cultured in the presence of either RK or S-Ag. In addition antibodies directed against the S-Ag were detected in both groups. These findings, in addition to the biochemical similarities of these preparations, reported elsewhere, would strongly suggest that RK and S-Ag are one and the same. The identification of potentially uveitogenic ocular antigens could help to rec...Continue Reading

References

Oct 1, 1975·American Journal of Ophthalmology·S OnoK Aoki
Nov 3, 1973·Lancet·D A BrewertonD C James
Oct 4, 1980·Lancet·R B NussenblattI Gery
Oct 1, 1980·Photochemistry and Photobiology·H Shichi, R L Somers
May 1, 1981·The British Journal of Ophthalmology·R B Nussenblatt, K K Mittal
Jun 1, 1981·Archives of Ophthalmology·R B NussenblattW B Wacker
Feb 1, 1980·American Journal of Ophthalmology·R B NussenblattW B Wacker
Jul 27, 1957·Journal of the American Medical Association·E WITEBSKYR W EGAN

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Citations

Jan 1, 1985·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H UusitaloA Palkama
Jul 30, 1983·Lancet·R B NussenblattI Gery
May 15, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·R M BroekhuyseA J Verkleij
Dec 2, 2014·Progress in Retinal and Eye Research·Jonas KuiperTimothy Radstake
Jun 1, 1985·Current Eye Research·R M Broekhuyse, H J Winkens
May 1, 1985·Current Eye Research·R M BroekhuyseH J Winkens
Jan 1, 1985·Current Eye Research·R M BroekhuyseA J Verkley
Dec 1, 1983·Experimental Eye Research·G M Borthwick, J V Forrester

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