PMID: 2611681Dec 25, 1989Paper

Reserpine enhances amphetamine stereotypies without increasing amphetamine-induced changes in striatal dialysate dopamine

Brain Research
C W CallawayD S Segal

Abstract

Indirect evidence suggests that amphetamine (AMPH) releases dopamine (DA) from an extravesicular, cytoplasmic pool. Disruption of vesicular DA storage by reserpine has been hypothesized to increase the concentration of extravesicular DA available for release by AMPH, which is consistent with the observation that reserpine does not prevent but augments the behavioral response to AMPH. In order to more directly test this hypothesis, the in vivo microdialysis technique was used to concurrently examine the behavioral and striatal dopaminergic response to AMPH (1.25 or 2.5 mg/kg) 24 h following reserpine pretreatment (2.5 mg/kg). Reserpine decreased tissue levels of DA by approximately 90% and reduced baseline dialysate DA concentrations by approximately 80%. Reserpine augmented the behavioural effects of AMPH, particularly increasing the occurrence and intensity of stereotypies. In contrast, reserpine did not alter the amount or duration of AMPH-induced DA release. This observation confirms that DA release by AMPH does not depend on vesicular stores but is inconsistent with the hypothesis that augmentation or behaviour by reserpine results from increased striatal DA release.

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Citations

Jan 11, 1992·Journal of Neural Transmission. General Section·D E Dluzen, F T Kratko
Jun 3, 1996·European Journal of Pharmacology·J L NeisewanderA N Sussman
Mar 1, 1994·Neuropharmacology·K E Heslop, G Curzon
Apr 1, 1995·Journal of Neuroscience Methods·J Brodkin, J F Nash
Jul 1, 1995·Neurobiology of Aging·H KametaniJ A Joseph
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Kuczenski, D S Segal
Jul 1, 1991·Brain Research Bulletin·A LevyT M Rauch
Jun 16, 2005·Progress in Neurobiology·David SulzerAurelio Galli
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J LaHosteJ F Marshall
Jan 11, 2007·Annual Review of Pharmacology and Toxicology·Annette E FleckensteinGlen R Hanson
Mar 12, 2008·Reviews in the Neurosciences·Susanne NikolausHans-Wilhelm Müller
May 19, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Felix P MayerHarald H Sitte
Nov 19, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Sanders A McDougallJasmine A M Robinson

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