Resetting Human Naïve Pluripotency

Genetics & Epigenetics
Jifang XiaoLiangqi Xie


The rodent naive pluripotent state is believed to represent the preimplantation inner cell mass state of the developing blastocyst and can derive self-renewing pluripotent embryonic stem cells (ESCs) in vitro. Nevertheless, human ESCs exhibit epigenetic, metabolic, and transcriptomic characteristics more akin to primed pluripotent stem cells (PSCs) derived from the postimplantation epiblast. Understanding the genetic and epigenetic mechanisms that constrain human ESCs in the primed state is crucial for the human naive pluripotent state resetting and numerous applications in regenerative medicine. In this review, we begin by defining the naive and primed states in the murine model and compare the epigenetic characteristics of those states to the human PSCs. We also examine the various reprogramming schemes to derive the human naive pluripotent state. Finally, we discuss future perspectives of studying and deriving the human naive PSCs in the context of cellular engineering and regenerative medicine.


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Related Concepts

Metabolic Process, Cellular
Laboratory Procedures
Genetically Engineered Mouse
Regenerative Medicine
Pluripotent Stem Cells
Phage Display Peptide Library
Enhanced S-Cone Syndrome
Cell Engineering
Study of Epigenetics

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