Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex

Science
C LeeI Edery

Abstract

Circadian clocks can be reset by light stimulation. To investigate the mechanism of this phase shifting, the effects of light pulses on the protein and messenger RNA products of the Drosophila clock gene period (per) were measured. Photic stimuli perturbed the timing of the PER protein and messenger RNA cycles in a manner consistent with the direction and magnitude of the phase shift. In addition, the recently identified clock protein TIM (for timeless) interacted with PER in vivo, and this association was rapidly decreased by light. This disruption of the PER-TIM complex in the cytoplasm was accompanied by a delay in PER phosphorylation and nuclear entry and disruption in the nucleus by an advance in PER phosphorylation and disappearance. These results suggest a mechanism for how a unidirectional environmental signal elicits a bidirectional clock response.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S B KhalsaG D Block
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P E HardinM Rosbash
Dec 1, 1991·Current Opinion in Neurobiology·J S Takahashi
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N AroninW J Schwartz
Oct 1, 1989·Neuron·M Rosbash, J C Hall
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J C Dunlap, J F Feldman
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I EderyM Rosbash

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Citations

Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J C Leloup, A Goldbeter
Jan 10, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E RosatoC P Kyriacou
May 1, 1997·Bulletin of Mathematical Biology·R A BarrioP K Maini
Oct 23, 1998·Invertebrate Neuroscience : in·D S Saunders
Feb 14, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kenji TomiokaTaishi Yoshii
Apr 19, 2005·Histochemistry and Cell Biology·Radka ZávodskáFrantisek Sehnal
Aug 30, 2008·Molecular Neurobiology·Raphaelle Dubruille, Patrick Emery
Apr 28, 2001·Journal of Experimental Marine Biology and Ecology·L M.Z. ChícharoJ Regala
Jul 27, 2001·Journal of Insect Physiology·T L. PageG Griffeth
Jan 1, 1997·Endeavour·S C Hinton, W H Meck
Jan 1, 1997·Endeavour·S C Hinton, W H Meck
Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
May 25, 1999·Progress in Neurobiology·J Falcón
Apr 1, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·D GonzeA Goldbeter
Oct 31, 1998·Current Opinion in Genetics & Development·L D Wilsbacher, J S Takahashi
Oct 6, 1999·Current Opinion in Genetics & Development·S A Brown, U Schibler
Feb 18, 1998·Current Opinion in Neurobiology·M U Gillette
Nov 13, 1998·Current Opinion in Neurobiology·P E Hardin
Aug 8, 1998·Trends in Cell Biology·C B Green
Mar 6, 1999·Current Opinion in Microbiology·J J Loros
Mar 16, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasufumi ShigeyoshiHitoshi Okamura
May 7, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T IshikawaT Tanimura
May 7, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T TakumiH Okamura
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yoshimi NiwaMasahiro Ishiura
Nov 17, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E Rosato, C P Kyriacou
Jan 10, 1998·Photochemistry and Photobiology·T Roenneberg, R G Foster
Aug 25, 2000·Molecular and Cellular Biology·W V SoM Rosbash
Oct 5, 2001·Molecular and Cellular Biology·F J LinA Sehgal
Jun 1, 1997·Annual Review of Plant Physiology and Plant Molecular Biology·Susan S. GoldenTakao Kondo
Nov 1, 2001·Annual Review of Cell and Developmental Biology·S L HarmerS A Kay

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