Resetting the epigenome for heart regeneration

Seminars in Cell & Developmental Biology
Gregory A Quaife-RyanJames E Hudson

Abstract

In contrast to adults, recent evidence suggests that neonatal mice are able to regenerate following cardiac injury. This regenerative capacity is reliant on robust induction of cardiomyocyte proliferation, which is required for faithful regeneration of the heart following injury. However, cardiac regenerative potential is lost as cardiomyocytes mature and permanently withdraw from the cell cycle shortly after birth. Recently, a handful of factors responsible for the regenerative disparity between the adult and neonatal heart have been identified, but the proliferative response of adult cardiomyocytes following modulation of these factors rarely reaches neonatal levels. The inefficient re-induction of proliferation in adult cardiomyocytes may be due to the epigenetic landscape, which drastically changes during cardiac development and maturation. In this review, we provide an overview of the role of epigenetic modifiers in developmental processes related to cardiac regeneration. We propose an epigenetic framework for heart regeneration whereby adult cardiomyocyte identity requires resetting to a neonatal-like state to facilitate cell cycle re-entry and regeneration following cardiac injury.

References

May 9, 1991·Nature·M S BartolomeiS M Tilghman
Aug 1, 1996·Journal of Molecular and Cellular Cardiology·F LiA M Gerdes
Sep 15, 1997·Nucleic Acids Research·M Beato, K Eisfeld
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Nov 30, 2000·The Journal of Biological Chemistry·T I SlepakN H Bishopric
Jul 11, 2003·Developmental Cell·Masashi ToyodaTakashi Takeuchi
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hwei-Ling ChengKatrin F Chua
May 28, 2004·Cell·Huafeng XieThomas Graf
May 5, 2005·The Journal of Biological Chemistry·Jooyoung JungYoungsook Lee
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Feb 27, 2007·Cell·Bing LiJerry L Workman
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sunhwa HongKai Ge
Feb 7, 2008·The Journal of Biological Chemistry·Tomohide TakayaKoji Hasegawa
May 9, 2008·Cell Stem Cell·Sol EfroniEran Meshorer
Oct 3, 2008·The Journal of Clinical Investigation·Rusty L MontgomeryEric N Olson
Mar 31, 2009·Nature Biotechnology·Madeleine P BallGeorge M Church
Aug 5, 2009·The Journal of Clinical Investigation·Nagalingam R SundaresanMahesh P Gupta
Aug 26, 2009·Cell·Jose SilvaAustin Smith
Feb 6, 2010·Genome Research·Louise LaurentChia-Lin Wei
Sep 14, 2010·Developmental Cell·Chinmay M TrivediJonathan A Epstein
Jan 8, 2011·Cell Stem Cell·Richard P KocheAlexander Meissner
Feb 4, 2011·Genes & Development·Anh T NguyenYi Zhang
Feb 5, 2011·Circulation Research·Pei HanChing-Pin Chang
Feb 16, 2011·Cell Research·Andrew J Bannister, Tony Kouzarides
Feb 26, 2011·Science·Enzo R PorrelloHesham A Sadek

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Citations

Mar 12, 2016·Biochemical and Biophysical Research Communications·Xiangwen PengTao P Zhong
Jun 1, 2016·The Journal of Cell Biology·Esther AixIgnacio Flores
Jul 25, 2017·Circulation·Gregory A Quaife-RyanEnzo R Porrello
Jul 22, 2017·Circulation Research·Xuejun Yuan, Thomas Braun
Jun 10, 2020·Cardiovascular Research·Giovanni Maroli, Thomas Braun
May 10, 2019·APL Bioengineering·Richard J Mills, James E Hudson
Jul 1, 2020·Current Cardiology Reports·Christopher A P BathoJames E Hudson
May 29, 2021·Pediatric Cardiology·Galip Servet AslanFatih Kocabas
Jul 1, 2021·Cold Spring Harbor Perspectives in Biology·Hui-Min YinCaroline E Burns

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