PMID: 2116519Jun 1, 1990Paper

Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate

Journal of Pharmacokinetics and Biopharmaceutics
M S RobertsL McLeod

Abstract

The residence time distributions of sucrose and taurocholate have been determined from the outflow concentration-time profiles after bolus input into an in situ perfused rat liver preparation. The normalized variance (and the dispersion number) appeared to be independent of perfusate flow rate (10 to 37 ml/min) and perfusate albumin concentration (0.5%). The apparent volume of distribution for sucrose appeared to increase with flow rate but was unaffected by the concentration of albumin (0-5%) present in the perfusate. The changes in taurocholate availability with flow rate were adequately accounted for by the dispersion model, whereas taurocholate availability-protein binding changes required an albumin-mediated transport model to be used in conjunction with the dispersion model.

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Citations

Feb 24, 2007·European Journal of Drug Metabolism and Pharmacokinetics·Yasemin Karabey, Selma Sahin
Sep 1, 1992·The Journal of Pharmacy and Pharmacology·Z Hussein, M Rowland
Nov 19, 1997·The Journal of Pharmacy and Pharmacology·G D Mellick, M S Roberts
Mar 21, 1998·The Journal of Pharmacy and Pharmacology·D Y HungM S Roberts
Mar 23, 2013·Journal of Pharmacological and Toxicological Methods·Hossein-Ali ArabMichael S Roberts
May 28, 2009·Journal of Pharmaceutical Sciences·Kent J FanningMichael S Roberts
Aug 4, 1998·Journal of Pharmaceutical Sciences·D Y HungM S Roberts
Jul 20, 2007·The Journal of Pharmacy and Pharmacology·Urban Fagerholm
Jul 1, 1999·Toxicology and Applied Pharmacology·G D Mellick, M S Roberts
Aug 12, 1999·Journal of Theoretical Biology·Y G AnissimovM S Roberts
Apr 1, 1995·Journal of Pharmacokinetics and Biopharmaceutics·H YasuiT Nakagawa
Oct 6, 2000·The Journal of Physiology·S Sahin, M Rowland
Apr 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·M V St-PierreK S Pang
Apr 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·J M Díaz-GarcíaM Rowland
Feb 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·L P RivoryS M Pond
Apr 20, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jasleen K SodhiLeslie Z Benet
Sep 4, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daniel Y HungMichael S Roberts
Mar 29, 2005·Molecular and Cellular Biochemistry·F J BurczynskiS Robert
Aug 4, 1998·The American Journal of Physiology·S Sahin, M Rowland
Mar 4, 2000·The Journal of Pharmacy and Pharmacology·I BernusR H Mortimer

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