Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways

The Journal of Immunology : Official Journal of the American Association of Immunologists
Yifan ZhanAndrew M Lew

Abstract

IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the second. It has been generally viewed that the resident CD8(+) dendritic cell (DC) subset is the predominant IL-12-producing cell type. In this study, we found, although this is so under steady state conditions, under inflammatory conditions monocyte-derived DC (mDC) became a major cell type producing IL-12. Depletion of either type of DC resulted in reduced production of IL-12 in vivo. For CD8(+) DC, IL-12 production could be stimulated by various pathways viz. signaling through MyD88, Trif, or nucleotide-binding oligomerization domain (Nod)-like receptors. In contrast, for mDC, IL-12 production was mainly dependent on MyD88 signaling. Thus, conventional DCs and mDCs use different pathways to regulate IL-12 production.

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Citations

Feb 23, 2017·Annual Review of Immunology·Sakeen W KashemDaniel H Kaplan
Jul 19, 2012·European Journal of Immunology·Yifan ZhanYuekang Xu
Sep 26, 2014·Arthritis Research & Therapy·Susan A OlalekanAlison Finnegan
Apr 14, 2019·Cancers·Ben WylieJason Waithman
Nov 2, 2011·Journal of Pharmacological Sciences·Jingxian ZengLiling Lin
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Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyun-Ja KoAndrew M Lew
Jul 27, 2011·Vaccine·Jose Rey-LadinoRonald Quinn

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