Resident cardiac progenitor cells: at the heart of regeneration.

Journal of Molecular and Cellular Cardiology
Sveva BolliniPaul R Riley

Abstract

Stem cell therapy has recently emerged as an innovative strategy over conventional cardiovascular treatments to restore cardiac function in patients affected by ischemic heart disease. Various stem cell populations have been tested and their potential for cardiac repair has been analyzed. Embryonic stem cells retain the greatest differentiation potential, but concerns persist with regard to their immunogenic and teratogenic effects. Although adult somatic stem cells are not tumourigenic and easier to use in an autologous setting, they exist in small numbers and possess reduced differentiation potential. Traditionally the heart was considered to be a post-mitotic organ; however, this dogma has recently been challenged with the identification of a reservoir of resident stem cells, defined as cardiac progenitor cells (CPCs). These endogenous progenitors may represent the best candidates for cardiovascular cell therapy, as they are tissue-specific, often pre-committed to a cardiac fate, and display a greater propensity to differentiate towards cardiovascular lineages. This review will focus on current research into the biology of CPCs and their regenerative potential. This article is part of a special issue entitled, "Cardiovascula...Continue Reading

References

Oct 13, 2001·The New England Journal of Medicine·S V RamanP F Binkley
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
May 30, 2002·Journal of Anatomy·C MummeryM Pera
Oct 22, 2002·FEBS Letters·Andrée M HierlihyLynn A Megeney
Aug 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekPiero Anversa
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Jan 2, 2004·The Journal of Biological Chemistry·Katsuhisa MatsuuraIssei Komuro
Jan 28, 2004·The Journal of Cell Biology·Roberta PalumboMarco E Bianchi
Jul 13, 2004·Lancet·A Mathur, J F Martin
Aug 18, 2004·Biochemical Pharmacology·Roberta Palumbo, Marco E Bianchi
Oct 9, 2004·Circulation Research·Elisa MessinaAlessandro Giacomello
Oct 20, 2004·The Journal of Cell Biology·Katsuhisa MatsuuraIssei Komuro
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Mar 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Buddhadeb DawnRoberto Bolli
Jun 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekPiero Anversa
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Axel LinkePiero Anversa
Jun 14, 2005·The Journal of Clinical Investigation·Nathalie Rosenblatt-VelinThierry Pedrazzini
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Luciano C AmadoJoshua M Hare
Sep 28, 2005·The Journal of Cell Biology·Yuichi TomitaKeiichi Fukuda
Oct 4, 2005·Journal of Molecular and Cellular Cardiology·Carmen UrbichStefanie Dimmeler
Nov 26, 2005·Angiogenesis·Robert J Tomanek
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekAnnarosa Leri
Dec 16, 2006·Reproductive Biomedicine Online·Karl-Henrik GrinnemoGöran Dellgren
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Harald C OttDoris A Taylor
Mar 24, 2007·Stem Cells·Christina Holmes, William L Stanford
May 15, 2007·Annals of the New York Academy of Sciences·Nicola SmartPaul R Riley
Jun 30, 2007·Annals of the New York Academy of Sciences·Deepak SrivastavaIldiko Bock-Marquette
Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Claudia BearziPiero Anversa
Oct 20, 2007·Circulation Research·Federica LimanaMaurizio C Capogrossi
Oct 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marcello RotaPiero Anversa
Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jochen TillmannsPiero Anversa

❮ Previous
Next ❯

Citations

Mar 15, 2012·Future Cardiology·Emma Siân Pincott, Michael Burch
Jun 7, 2014·Nature Communications·Gemma M BalmerPaul R Riley
Apr 3, 2014·Basic Research in Cardiology·Ying-Ying ZhangGui-Rong Li
Jul 8, 2014·Antioxidants & Redox Signaling·Wataru KimuraHesham A Sadek
Mar 19, 2014·Tissue Engineering. Part C, Methods·Cristina Martínez-RamosManuel Monleón Pradas
Dec 3, 2014·Carbohydrate Polymers·Amanda K A SilvaDidier Letourneur
Sep 13, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mathieu C RémondLeonard M Eisenberg
Feb 14, 2012·Current Opinion in Organ Transplantation·Guerard W Byrne, Christopher G A McGregor
Sep 25, 2012·Heart Failure Reviews·Alexander T Akhmedov, José Marín-García
Jun 10, 2011·Journal of Cardiovascular Translational Research·Emil RuvinovSmadar Cohen
May 12, 2012·Cardiology Research and Practice·Marie-Noëlle GiraudHendrik T Tevaearai
Apr 3, 2012·Biologie aujourd'hui·Philippe Menasché
Jan 31, 2016·Seminars in Cell & Developmental Biology·Yihua BeiJunjie Xiao
Apr 12, 2015·Journal of Molecular and Cellular Cardiology·Christie Aguiar, Keith R Brunt
Aug 21, 2012·Vascular Pharmacology·Nicola SmartPaul R Riley
Jun 2, 2012·Differentiation; Research in Biological Diversity·Adriana C Gittenberger-de GrootRobert E Poelmann
Jan 25, 2012·Pharmacology & Therapeutics·Naama Zeevi-LevinOfer Binah
Jul 26, 2011·Comptes rendus biologies·Philippe Menasché
Mar 5, 2011·Advanced Drug Delivery Reviews·Zhaoyang YeWensong Tan
Jan 30, 2016·Stem Cells International·Aleksandra Klimczak, Urszula Kozlowska
Apr 19, 2015·Journal of Molecular and Cellular Cardiology·Nirmala Hariharan, Mark A Sussman
May 6, 2011·Stem Cells·Nuria San MartinBeatriz G Galvez
Nov 6, 2012·Cell Biology International Reports·Leilei LuJingjing Lu
Mar 6, 2012·British Journal of Pharmacology·Joaquim M Vieira, Paul R Riley
Oct 21, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Adam W Feinberg
Jul 10, 2013·Journal of cardiology·Vincenzo GrimaldiClaudio Napoli
Jun 11, 2015·Journal of Cellular and Molecular Medicine·Yihua BeiJunjie Xiao
Mar 23, 2011·Developmental Biology·Varsha K KhodiyarRuth C Lovering
Sep 2, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Robert J Boucek JrAnn Steele
Apr 23, 2016·Journal of Cardiac Failure·Valentina MercurioPietro Ameri
Jan 13, 2015·Cellular and Molecular Life Sciences : CMLS·Patrizia NigroGiulio Pompilio
Jun 12, 2013·Cell Stem Cell·Jessica C Garbern, Richard T Lee
Jun 9, 2016·Journal of Molecular and Cellular Cardiology·Jianyun YanChen-Leng Cai
Jun 9, 2016·BMC Endocrine Disorders·Marek JankowskiJolanta Gutkowska
Oct 23, 2016·Pharmacology & Therapeutics·Chiara CencioniFrancesco Spallotta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.