Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age

Frontiers in Cell and Developmental Biology
Raquel Rua MartinsCatarina Martins Henriques

Abstract

The zebrafish has emerged as an exciting vertebrate model to study different aspects of immune system development, particularly due to its transparent embryonic development, the availability of multiple fluorescent reporter lines, efficient genetic tools and live imaging capabilities. However, the study of immunity in zebrafish has largely been limited to early larval stages due to an incomplete knowledge of the full repertoire of immune cells and their specific markers, in particular, a lack of cell surface antibodies to detect and isolate such cells in living tissues. Here we focus on tissue resident or associated immunity beyond development, in the adult zebrafish. It is our view that, with our increasing knowledge and the development of improved tools and protocols, the adult zebrafish will be increasingly appreciated for offering valuable insights into the role of immunity in tissue repair and maintenance, in both health and disease throughout the lifecourse.

References

Sep 1, 1991·Brain Research. Molecular Brain Research·J PoirierC E Finch
Sep 1, 1994·Journal of Neuropathology and Experimental Neurology·S H HanD E Schmechel
Oct 7, 1998·Progress in Neurobiology·M A Cuadros, J Navascués
Feb 8, 2003·Science·David M LangenauA Thomas Look
Apr 16, 2004·Immunity·Nikolaus S TredeLeonard I Zon
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·David M LangenauNikolaus S Trede
Jan 18, 2005·Mechanisms of Development·Kenneth N WallaceMichael Pack
Aug 30, 2005·Developmental Biology·Annie N Y NgJoan K Heath
Apr 19, 2006·Nature Reviews. Genetics·Cécile CrosnierJulian Lewis
May 4, 2006·Cell Motility and the Cytoskeleton·Michael J ReddPaul Martin
May 12, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qin XuYadong Huang
Jul 15, 2006·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach
Aug 24, 2006·Blood·Stephen A RenshawMoira K B Whyte
Sep 12, 2006·Journal of Leukocyte Biology·Jonathan R MathiasAnna Huttenlocher
May 5, 2007·BMC Developmental Biology·Chris HallPhil Crosier
Feb 6, 2008·Zebrafish·Peter F Hitchcock, Pamela A Raymond
Nov 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Isaac M ChiuMichael C Carroll
Dec 24, 2008·The Journal of Clinical Investigation·Vanessa BrochardStéphane Hunot
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·María P SepulcreVictoriano Mulero
May 26, 2009·Progress in Retinal and Eye Research·Ashutosh P JadhavConstance L Cepko
Jul 22, 2009·Developmental and Comparative Immunology·Jonathan R MathiasAnna Huttenlocher
Dec 17, 2009·Immunogenetics·Jeffrey A YoderGary W Litman
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Geanncarlo Lugo-VillarinoDavid Traver
Nov 19, 2010·Blood·Felix EllettGraham J Lieschke
Mar 4, 2011·Current Drug Targets·Annemarie H Meijer, Herman P Spaink
Mar 17, 2011·Blood·Valerie WittamerDavid Traver
May 20, 2011·Developmental Neurobiology·Gaia GestriStephan C F Neuhauss
Jan 10, 2012·Disease Models & Mechanisms·Stephen A Renshaw, Nikolaus S Trede
Jan 20, 2012·Mucosal Immunology·Nicole P MalvinThaddeus S Stappenbeck
Jun 1, 2012·Developmental Neurobiology·Adam J SvahnThomas S Becker
Jun 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yona GoldshmitPeter D Currie
Jul 18, 2012·EMBO Reports·Johanna Pott, Mathias Hornef

❮ Previous
Next ❯

Citations

Dec 25, 2019·Cellular Microbiology·Erika M FloresAnne Marie Krachler
Sep 29, 2020·Translational Vision Science & Technology·Alison L HuckenpahlerRoss F Collery
Dec 24, 2019·Frontiers in Immunology·Arkadi ShwartzChunyue Yin
Mar 27, 2020·Frontiers in Cellular and Infection Microbiology·Marinela ContrerasJosé de la Fuente

❮ Previous
Next ❯

Methods Mentioned

BETA
single-cell sequencing
transgenic
dissection
confocal microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.