Resident progenitors and bone marrow stem cells in myocardial renewal and repair

Nature Clinical Practice. Cardiovascular Medicine
Simón Méndez-FerrerBernardo Nadal-Ginard

Abstract

Although cardiac transplantation is still the treatment of choice for end-stage heart disease, the side effects derived from the use of immunosuppressants and the limited availability of donors have prompted the search for alternative therapeutic strategies. Among other possibilities, cell transplantation approaches have recently emerged as new alternatives to stimulate myocardial regeneration. These approaches are mainly based on the increasing number of reports documenting the plasticity of stem cells of various origins, particularly the ability of several types of embryonic and adult stem cells to give rise to cardiomyocytes. Unprecedented in the field of 'translational research' and based on the urgent need for alternative therapies, the promising results obtained with animal models have been quickly transferred to the clinical arena, where numerous small pilot studies using different cell types are already ongoing and/or have reported promising results. Nevertheless, the lack of randomization, the variability and small size of the treated cohorts and the use of mixed populations of cells have often clouded the significance and prevented a mechanistic interpretation of the results. Here, we briefly review the use of bone-ma...Continue Reading

References

Mar 13, 1999·The Journal of Clinical Investigation·S MakinoS Ogawa
Nov 26, 1999·Circulation·S Oparil
Oct 24, 2000·The Journal of Thoracic and Cardiovascular Surgery·J S WangR C Chiu
Apr 5, 2001·Nature·D OrlicP Anversa
Jun 8, 2001·The Journal of Clinical Investigation·K A JacksonM A Goodell
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·D OrlicP Anversa
Oct 3, 2001·The Journal of Thoracic and Cardiovascular Surgery·J S WangR C Chiu
Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Jan 24, 2002·Nature·Piero Anversa, Bernardo Nadal-Ginard
Apr 6, 2002·Circulation Research·Michael A LaflammeCharles E Murry
May 9, 2002·The Annals of Thoracic Surgery·Kimikazu HamanoMasunori Matsuzaki
Jun 14, 2002·The Journal of Thoracic and Cardiovascular Surgery·Shinji TomitaRen-Ke Li
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
Jul 18, 2002·The Annals of Thoracic Surgery·Takayuki SaitoRay C J Chiu
Jan 9, 2003·Lancet·Christof StammGustav Steinhoff
Jan 29, 2003·Circulation·Alice K Jacobs
Feb 8, 2003·Circulation Research·Bernardo Nadal-GinardPiero Anversa
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Shinya FukuharaTakeshi Nakatani
Jul 24, 2003·Circulation·Spencer B King
Jul 25, 2003·The Journal of Thoracic and Cardiovascular Surgery·Takayuki SaitoRay C-J Chiu
Aug 19, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Leonard M EisenbergCarol A Eisenberg
Aug 30, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hai-Feng DuanLi-Sheng Wang
Sep 12, 2003·Journal of Molecular and Cellular Cardiology·Mitsuhiro KudoMuhammad Ashraf
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Oct 15, 2003·Circulation·Jeffrey A Cutler, Thomas Thom
Jan 2, 2004·The Journal of Biological Chemistry·Katsuhisa MatsuuraIssei Komuro
Jan 21, 2004·Molecular Cell·Miguel Godinho FerreiraJulia Promisel Cooper
Mar 17, 2004·Circulation·Judith A AireyEsmail D Zanjani

❮ Previous
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Citations

Jan 12, 2010·Annual Review of Medicine·Stefan Janssens
Aug 21, 2013·Cellular and Molecular Life Sciences : CMLS·Domiziana CostamagnaMaurilio Sampaolesi
Jul 25, 2009·Current Treatment Options in Cardiovascular Medicine·David Angert, Steven R Houser
Feb 27, 2008·Journal of Cellular and Molecular Medicine·Hideshi OkadaHisayoshi Fujiwara
May 29, 2007·International Review of Neurobiology·Behrouz NikbinFatemeh Talebian
Feb 5, 2008·Asian Cardiovascular & Thoracic Annals·Koippallil G Aghila RaniChandrasekharan C Kartha
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Daniele TorellaBernardo Nadal-Ginard
Jan 19, 2007·Nature Clinical Practice. Cardiovascular Medicine·Georgina M EllisonBernardo Nadal-Ginard
Mar 6, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Longhu LiHisayoshi Fujiwara
Jan 20, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Hideshi OkadaShinya Minatoguchi
Feb 5, 2010·American Journal of Physiology. Cell Physiology·Yi HanMan-Wen Jin
Dec 10, 2009·Journal of Cardiovascular Medicine·Rosalinda Madonna, Raffaele De Caterina
Jan 15, 2015·Cardiovascular Drugs and Therapy·Vanessa-leigh van ZuylenDouwe E Atsma

❮ Previous
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