Residential radon and lung cancer in Sweden: risk analysis accounting for random error in the exposure assessment

Health Physics
Frédéric LagardeG A Swedjemark

Abstract

A large epidemiologic study on residential radon exposure and lung cancer has been conducted in Sweden. An attempt is now made to quantify the impact of random error in the exposure assessment on the risk estimate for lung cancer in this study. The study included 1,360 lung cancer cases, diagnosed from 1980 to 1984, and 2,847 population controls. Radon measurements were performed in 8,992 dwellings occupied by the study subjects some time since 1947. Questionnaires provided information on smoking and other risk factors. Imprecision in the retrospective exposure assessment for radon was estimated from a Monte Carlo technique modeling Swedish conditions. Adjusted risk estimates were obtained from regression analyses based on expected values for true time-weighted average residential radon concentration (TWA), conditional on observed TWA. Without adjustment for random error in the TWA estimates, the linear excess relative risk coefficient was 0.10 per 100 Bq m(-3), but an excess relative risk of about 0.15 to 0.20 per 100 Bq m(-3) was suggested following adjustment. The potentially significant consequences of errors in the retrospective radon exposure assessment should be taken into consideration in the risk estimation as well as ...Continue Reading

Citations

Aug 29, 2002·Journal of Exposure Analysis and Environmental Epidemiology·Frédéric LagardeGöran Pershagen
Apr 13, 2006·Journal of Toxicology and Environmental Health. Part a·Angelika Schaffrath RosarioH-Erich Wichmann
Apr 13, 2006·Journal of Toxicology and Environmental Health. Part a·Daniel KrewskiHomer B Wilcox
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Jul 1, 2006·Radiation Research·Daniel W Schafer, Ethel S Gilbert
Oct 13, 2009·Health Physics·Ethel S Gilbert
Dec 12, 2018·Radiation and Environmental Biophysics·Georgy MalinovskyAleksey Vasilyev
Feb 13, 2001·American Journal of Epidemiology·L KreienbrockH E Wichmann
Jun 21, 2001·Epidemiology·F LagardeG Pershagen
Feb 6, 2004·British Medical Bulletin·Paolo Boffetta, Fredrik Nyberg
Sep 23, 2003·Epidemiology·Michaela KreuzerH-Erich Wichmann
Dec 19, 2003·Radiation Research·Wolfgang F HeidenreichSuresh H Moolgavkar
Dec 14, 2004·Journal of Exposure Analysis and Environmental Epidemiology·Daniel KrewskiErnest G Létourneau
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