PMID: 6397028Oct 1, 1984Paper

Residual B-cell function in type 1 (insulin-dependent) diabetes mellitus: its relation to clinical and metabolic features

Acta diabetologica latina
E BonoraU Butturini

Abstract

The aim of the present study was to investigate whether or not residual B-cell function could be related to insulin sensitivity as well as to duration of disease, insulin requirement, and indices of metabolic control in a population of Type 1 (insulin-dependent) diabetic patients. A positive correlation was found between fasting C-peptide and age at onset of diabetes, whereas a negative relationship occurred between C-peptide and duration of disease. Fasting C-peptide negatively correlated also to mean daily plasma glucose, 24-h glycosuria, and fasting free fatty acid concentration. Moreover, a negative correlation was found between C-peptide and daily insulin requirement. Conversely, a positive relationship occurred between C-peptide levels and the parameter we used for estimating insulin sensitivity, i.e. glucose disappearance rate after i.v. insulin injection. These results once more emphasize the importance of residual B-cell function in Type 1 (insulin-dependent) diabetes mellitus, and suggest that the residual endogenous insulin secretion might play an important role in glucose homeostasis of Type 1 diabetes by influencing the sensitivity to insulin.

References

Jul 22, 1976·The New England Journal of Medicine·D L HorwitzA H Rubenstein
Jan 1, 1978·Diabetes·C Binder, O K Faber
Jan 1, 1978·Metabolism: Clinical and Experimental·D K YueJ R Turtle
Jul 1, 1978·Metabolism: Clinical and Experimental·A D CherringtonM S Harris
Feb 12, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·A NomaM Kita
May 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A H Christiansen
Jul 1, 1972·The Journal of Clinical Investigation·J WahrenR Luft
Aug 1, 1971·The Journal of Clinical Investigation·P Felig, J Wahren
Jul 1, 1982·Diabetes Care·J B HoekstraJ H Thijssen
Feb 1, 1980·Acta Endocrinologica·S MadsbadI Transbøl
Nov 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R S GrayB F Clarke

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Citations

Sep 1, 1995·Diabetes/metabolism Reviews·A GolayJ P Assal
Apr 30, 2003·Diabetes·Carla J GreenbaumUNKNOWN Immunology of Diabetes Society
Jul 12, 2002·Diabetes/metabolism Research and Reviews·Carla J Greenbaum
Jan 25, 2003·Clinical and Experimental Pharmacology & Physiology·Muniappan Latha, Leelavinothan Pari
Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Sougata GhoshBalu A Chopade
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Kalpana SridharanDeepak Panneerselvam

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