Residual chemoresponsiveness to acids in the superior laryngeal nerve in "taste-blind" (P2X2/P2X3 double-KO) mice.

Chemical Senses
Tadahiro OhkuriYuzo Ninomiya

Abstract

Mice lacking both the P2X2 and the P2X3 purinergic receptors (P2X-dblKO) exhibit loss of responses to all taste qualities in the taste nerves innervating the tongue. Similarly, these mice exhibit a near total loss of taste-related behaviors in brief access tests except for a near-normal avoidance of acidic stimuli. This persistent avoidance of acids despite the loss of gustatory neural responses to sour was postulated to be due to continued responsiveness of the superior laryngeal (SL) nerve. However, chemoresponses of the larynx are attributable both to taste buds and to free nerve endings. In order to test whether the SL nerve of P2X-dblKO mice remains responsive to acids but not to other tastants, we recorded responses from the SL nerve in wild-type (WT) and P2X-dblKO mice. WT mice showed substantial SL responses to monosodium glutamate, sucrose, urea, and denatonium-all of which were essentially absent in P2X-dblKO animals. In contrast, the SL nerve of P2X-dblKO mice exhibited near-normal responses to citric acid (50 mM) although responsiveness of both the chorda tympani and the glossopharyngeal nerves to this stimulus were absent or greatly reduced. These results are consistent with the hypothesis that the residual avoidan...Continue Reading

References

May 1, 1991·Journal of Neurophysiology·D V Smith, T Hanamori
May 31, 1988·Brain Research·J D Dickman, D V Smith
Feb 1, 1986·Brain Research Bulletin·T Hanamori, D V Smith
Jun 3, 1985·Brain Research·T Shingai, L M Beidler
Jan 1, 1981·The Japanese Journal of Physiology·Y Ninomiya, M Funakoshi
Jan 1, 1980·The Japanese Journal of Physiology·T Shingai
Jun 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J MiyazakiS Masuko
Mar 16, 2000·The American Journal of Medicine·Y YoshidaT Nakashima
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun-Ichi KitagawaYoshiaki Yamada
Oct 9, 2002·Nature Neuroscience·Cristian A PérezRobert F Margolskee
Nov 5, 2002·Brain Research. Molecular Brain Research·Yusuke IshidaShoichi Shimada
Nov 7, 2002·Physiology & Behavior·Yuka KajiiYoshiaki Yamada
Feb 4, 2003·The Journal of Physiology·T A RichterS D Roper
Jun 4, 2004·The Annals of Otology, Rhinology, and Laryngology·Toshiyuki UnoYasuo Hisa
Jul 1, 2004·Acta Oto-laryngologica·Shinobu KoikeYasuo Hisa
Aug 11, 2004·The Journal of Biological Chemistry·Long-Jun WuTian-Le Xu
Mar 7, 2006·Neuroscience Letters·Hiroyuki OkanoYasuo Hisa
Aug 24, 2007·The European Journal of Neuroscience·Keiko YasumatsuYuzo Ninomiya
Dec 28, 2007·Journal of Neurophysiology·Weihong LinDiego Restrepo
Feb 27, 2008·The Journal of Comparative Neurology·Brian GulbransenThomas E Finger
Aug 21, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer M Stratford, Robert J Contreras
Oct 7, 2010·Pflügers Archiv : European journal of physiology·Maxime G Blanchard, Stephan Kellenberger
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rui B ChangEmily R Liman
Jan 15, 2011·BMC Pulmonary Medicine·Marco TizzanoThomas E Finger
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catherine Peyrot des GachonsPaul A S Breslin
May 18, 2011·The Journal of General Physiology·Yuanyuan Y WangEmily R Liman
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M Stratford, Thomas E Finger

❮ Previous
Next ❯

Citations

Jul 11, 2012·Histochemistry and Cell Biology·G Krasteva, W Kummer
Feb 15, 2013·Nature·Yuki OkaCharles S Zuker
Apr 26, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maartje C P Geraedts, Steven D Munger
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer M Stratford, Thomas E Finger
May 17, 2014·Chemical Senses·Anthony Sclafani, Karen Ackroff
Oct 18, 2015·Histochemistry and Cell Biology·Natsumi TakahashiYoshio Yamamoto
Mar 13, 2014·Neuron·Emily R LimanCraig Montell
Jun 14, 2016·The Journal of Comparative Neurology·Jennifer M StratfordThomas E Finger
Mar 3, 2018·Science·Craig Montell
Nov 24, 2018·Journal of Anatomy·Haruka MasudaYoshio Yamamoto
Jul 19, 2013·Physiological Genomics·Michael G Tordoff, Hillary T Ellis
Dec 19, 2018·Pharmacological Reviews·R Kyle Palmer
Oct 1, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mohammad Zakir HossainJunichi Kitagawa
Feb 2, 2020·Cellular and Molecular Life Sciences : CMLS·Ranier GutierrezSidney A Simon
Jun 24, 2020·American Journal of Physiology. Endocrinology and Metabolism·Ana Andres-HernandoMiguel A Lanaspa
Sep 2, 2020·International Journal of Molecular Sciences·Mohammad Zakir HossainJunichi Kitagawa
Dec 21, 2018·International Journal of Molecular Sciences·Mohammad Zakir HossainJunichi Kitagawa
Jan 23, 2021·International Journal of Molecular Sciences·Mojca JensterleAndrej Janez
May 4, 2020·Cell·Yalda MoayediJoriene C de Nooij

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.