Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer: Results of a prospective study

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Silke TribiusSusanne Singer

Abstract

Patients with locally advanced head and neck cancer (LAHNC) undergo life-changing treatments that can seriously affect quality of life (QoL). This prospective study examined the key QoL domains during the first year after intensity-modulated radiotherapy (IMRT) and identified predictors of these changes in order to improve patient outcomes. A consecutive series of patients with LAHNC completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core module (QLQ-C30) and the HNC-specific QLQ-HN35 before (t0) and at the end (t1) of definitive or adjuvant IMRT, then at 6-8 weeks (t2), 6 months (t3), and 1 year (t4) after IMRT. Patients (n = 111) completing questionnaires at all five time points were included (baseline response rate: 99%; dropout rate between t0 and t4: 5%). QoL deteriorated in all domains during IMRT and improved slowly during the first year thereafter. Many domains recovered to baseline values after 1 year but problems with smelling and tasting, dry mouth, and sticky saliva remained issues at this time. Increases in problems with sticky saliva were greater after 1 year in patients with definitive versus adjuvant IMRT (F = 3.5, P = 0.05). QoL in patients with LAHNC ...Continue Reading

References

Dec 1, 1996·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·M T King
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K KobayashiK Yoshida
Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K BjordalS Kaasa
Apr 4, 2003·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Siri Beier JensenBirgitte Nauntofte
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Alexander LinAvraham Eisbruch
May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Jolie RingashBernard Cummings
Jul 1, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P M Harari
Dec 22, 2005·The Laryngoscope·Helmut AbendsteinKristin Bjordal
Dec 22, 2007·Head & Neck·Mats NordgrenMagnus Jannert
Oct 30, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mia VoordeckersGuy Storme
Apr 23, 2010·Oral Oncology·S A Bhide, C M Nutting
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V GrégoireUNKNOWN EHNS-ESMO-ESTRO Guidelines Working Group
Nov 1, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Julia MaurerOliver Kölbl
Nov 8, 2011·International Journal of Radiation Oncology, Biology, Physics·Michael LittleAvraham Eisbruch
Jan 31, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Zhiqiang MengLorenzo Cohen
May 15, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W K W SoC W H Chan
Oct 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Klaudia U HunterAvraham Eisbruch
Nov 29, 2012·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Susanne SingerDirk Hofmeister
Jan 29, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S TribiusP Tennstedt

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Citations

Feb 8, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Carmen StrombergerSimone Marnitz
Oct 28, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Christina SchröderAndré Buchali
Jul 23, 2019·Head & Neck·Margot BaudeletFréderic Duprez
May 20, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Alexandria HarrisMarci Lee Nilsen
Apr 27, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Michael OertelHans Theodor Eich
Jun 3, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Philipp KörnerBirgitt van Oorschot
May 8, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S TribiusC Bergelt
Jan 11, 2019·World Journal of Clinical Oncology·Sung Jun MaAnurag K Singh
May 11, 2019·Dysphagia·Julie Killerup KaaeJesper Grau Eriksen
Feb 2, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S MogadasS Tribius
Dec 31, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Silke TribiusCorinna Bergelt
May 7, 2020·Clinical and Translational Radiation Oncology·Sonja StiebUNKNOWN MD Anderson Head and Neck Cancer Symptom Working Group
Apr 19, 2021·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Rachel BarrySarah Barrett
Oct 11, 2021·BMC Oral Health·Ulrica AlmhöjdAnnica Almståhl

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