Residual deformations in ocular tissues

Journal of the Royal Society, Interface
Ruoya WangC Ross Ethier

Abstract

Residual deformations strongly influence the local biomechanical environment in a number of connective tissues. The sclera is known to be biomechanically important in healthy and diseased eyes, such as in glaucoma. Here, we study the residual deformations of the sclera, as well as the adjacent choroid and retina. Using freshly harvested porcine eyes, we developed two approaches of quantifying residual deformations in the spherically shaped tissues of interest. The first consisted of punching discs from the posterior wall of the eye and quantifying the changes in the area and eccentricity of these samples. The second consisted of cutting a ring from the equatorial sclera and making stress-relieving cuts in it. Measurements of curvature were made before and after the stress-relieving cuts. Using the first approach, we observed a 42% areal contraction of the choroid, but only modest contractions of the sclera and retina. The observed contractions were asymmetric. In the second approach, we observed an opening of the scleral rings (approx. 10% decrease in curvature). We conclude that residual bending deformations are present in the sclera, which we speculate may be due to radially heterogeneous growth and remodelling of the tissue ...Continue Reading

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Citations

Feb 14, 2016·Journal of the Mechanical Behavior of Biomedical Materials·T AhamedR W Ogden
Jun 28, 2015·Experimental Eye Research·Thao D Nguyen, C Ross Ethier
Nov 29, 2016·Journal of Biomechanical Engineering·Ruoya WangRudolph L Gleason
Oct 30, 2021·Investigative Ophthalmology & Visual Science·Satish K PandaMichaël J A Girard

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