Residual effects of sleep medication on driving ability

Sleep Medicine Reviews
Joris C VersterEdmund R Volkerts

Abstract

Most patients using hypnotics are ambulatory and presumably have a job and drive a car. Since driving a car is one of the most common but potentially dangerous daily activities, hypnotics should act rapidly when needed, but daytime sleepiness and other residual effects that may impair performance are unwanted. This review summarizes the effects of hypnotics on driving ability as determined with the on-the-road driving test during normal traffic. Supportive evidence from epidemiological data, and results from driving simulators and closed-road studies are also considered. On-the-road studies revealed that benzodiazepine hypnotics significantly impaired driving ability the morning following bedtime administration. Impairment was sometimes also significant in the afternoon (16-17 h after administration). Similar driving impairment was observed with zopiclone. However, the magnitude of impairment depends on various factors including the half-life and dosage of the drug, and the time after administration. The results from on-the-road driving studies are supported by evidence obtained in driving simulators and laboratory tests. Epidemiological data and on-the-road studies show that tolerance develops to the impairing effects of hypno...Continue Reading

References

May 12, 1979·British Medical Journal·A P Presley
Oct 1, 1992·Journal of Geriatric Psychiatry and Neurology·L R Kapust, S Weintraub
Oct 1, 1992·American Journal of Epidemiology·W A RayM D Decker
Dec 1, 1990·American Journal of Public Health·G OsterM W Russell
Jan 1, 1990·European Journal of Clinical Pharmacology·K A BrookhuisJ F O'Hanlon
Aug 1, 1990·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·T GalskiR L Bruno
Apr 1, 1989·Accident; Analysis and Prevention·J A Groeger, I D Brown
Aug 1, 1989·Accident; Analysis and Prevention·M SivakU Tränkle
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·U SchmidtE Rüther
Jan 1, 1986·Acta Psychiatrica Scandinavica. Supplementum·J F O'Hanlon, E R Volkerts
Jun 1, 1986·Accident; Analysis and Prevention·I A McCormickD E Green
Aug 1, 1986·Accident; Analysis and Prevention·M L Matthews, A R Moran
Sep 25, 1982·British Medical Journal·T A Betts, J Birtle
Jan 1, 1984·British Journal of Clinical Pharmacology·J F O'Hanlon
Jul 2, 1982·Science·J F O'HanlonJ B Riemersma
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H W Robbe, J F O'Hanlon
May 3, 1995·JAMA : the Journal of the American Medical Association·L J FittenS Ganzell
Jul 1, 1994·Journal of Gerontology·G L OdenheimerK L Minaker
May 1, 1993·Journal of Analytical Toxicology·B P Joynt
Aug 21, 1993·BMJ : British Medical Journal·F M Nouri, N B Lincoln
Feb 1, 1996·Archives of Physical Medicine and Rehabilitation·J E Korteling, N A Kaptein
Jul 2, 1997·JAMA : the Journal of the American Medical Association·B HemmelgarnG Pinard
Apr 1, 1998·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·J M DuchekJ C Morris
May 20, 1998·Journal of the American Geriatrics Society·R A MarottoliM E Tinetti
Nov 5, 1998·Lancet·F BarboneT M MacDonald
Aug 10, 1999·Accident; Analysis and Prevention·A J McKnight, A S McKnight
Oct 10, 2000·Perceptual and Motor Skills·R S MyersK T Goode
Apr 3, 2001·Trends in Pharmacological Sciences·U RudolphH Möhler
Apr 20, 2001·The New England Journal of Medicine·D R Weinberger
Oct 24, 2001·Forensic Science International : Synergy·H DruidJ Ahlner
Nov 2, 2001·Brain Injury : [BI]·A Lundqvist
Jan 10, 2002·The Clinical Neuropsychologist·R De Raedt, I Ponjaert-Kristoffersen
Jul 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joris C VersterMarinus N Verbaten
Jul 26, 2002·International Journal of Clinical Pharmacology and Therapeutics·A IudiceL Murri

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Citations

Jun 8, 2014·Der Nervenarzt·G Laux, A Brunnauer
May 15, 2009·International Journal of Environmental Research and Public Health·Joris C Verster, Monique A J Mets
Jan 1, 2010·Drug, Healthcare and Patient Safety·Alon Y AvidanRobert W Baran
Feb 14, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Naren Gunja
Mar 5, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Naren Gunja
Oct 26, 2005·Journal of Community Health Nursing·Philippe VoyerMichel Préville
Oct 17, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mei-Feng TangChia-Chin Lin
Apr 28, 2010·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Philippe VoyerSarah-Gabrielle Béland
Mar 21, 2013·Accident; Analysis and Prevention·Andrea Jane HickeyUNKNOWN Candrive Research Team
Mar 20, 2012·Expert Opinion on Pharmacotherapy·David J Greenblatt, Thomas Roth
Nov 7, 2012·Expert Opinion on Drug Metabolism & Toxicology·David J Greenblatt, Gary K Zammit
Nov 26, 2015·Sleep Medicine Reviews·Annette van MaanenFrans J Oort
Apr 2, 2013·Semergen·M D Díez-JuárezA M Pérez-La Orden
Aug 14, 2012·Sleep Medicine Reviews·Joris C Verster, Thomas Roth
Mar 4, 2011·Sleep Medicine Reviews·Mark R Pressman
Feb 23, 2010·Sleep Medicine Reviews·Monique A J MetsJoris C Verster
Apr 4, 2006·Obstetrics and Gynecology
Oct 18, 2008·Journal of Forensic and Legal Medicine·B E SminkA C G Egberts
Sep 3, 2011·Journal of the American Geriatrics Society·Lynn B MeulenersJonathon Q Ng
Jun 26, 2012·Statistics in Medicine·Eugene LaskaJoseph Wanderling
May 7, 2011·Drug and Alcohol Review·Stefanie Y Leung
Jun 10, 2010·Journal of Psychiatric and Mental Health Nursing·P VoyerM Préville
Aug 5, 2015·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Janet M Y CheungBandana Saini
Oct 9, 2014·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Cheng-Fang YenCheng-Sheng Chen
Oct 15, 2013·Behaviour Research and Therapy·Kenneth L LichsteinChristina S McCrae
Sep 26, 2014·Therapeutic Drug Monitoring·Pirkko KriikkuIlkka Ojanperä
Jun 29, 2014·Forensic Science International : Synergy·Karlijn D B BezemerJohan J de Gier
Dec 3, 2014·Clinical Therapeutics·James MacFarlaneJacques Montplaisir

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