Residual inhibition functions overlap tinnitus spectra and the region of auditory threshold shift.

Journal of the Association for Research in Otolaryngology : JARO
Larry E RobertsDaniel J Bosnyak

Abstract

Animals exposed to noise trauma show augmented synchronous neural activity in tonotopically reorganized primary auditory cortex consequent on hearing loss. Diminished intracortical inhibition in the reorganized region appears to enable synchronous network activity that develops when deafferented neurons begin to respond to input via their lateral connections. In humans with tinnitus accompanied by hearing loss, this process may generate a phantom sound that is perceived in accordance with the location of the affected neurons in the cortical place map. The neural synchrony hypothesis predicts that tinnitus spectra, and heretofore unmeasured "residual inhibition functions" that relate residual tinnitus suppression to the center frequency of masking sounds, should cover the region of hearing loss in the audiogram. We confirmed these predictions in two independent cohorts totaling 90 tinnitus subjects, using computer-based tools designed to assess the psychoacoustic properties of tinnitus. Tinnitus spectra and residual inhibition functions for depth and duration increased with the amount of threshold shift over the region of hearing impairment. Residual inhibition depth was shallower when the masking sounds that were used to induce...Continue Reading

References

Dec 1, 1990·Ear and Hearing·F K KukH Jordan
Apr 15, 1989·The Journal of Comparative Neurology·D Robertson, D R Irvine
May 1, 1971·Audiology : Official Organ of the International Society of Audiology·H Feldmann
Sep 1, 1984·Journal of Speech and Hearing Research·R S TylerP A Smith
Nov 1, 1983·British Journal of Audiology·A M TerryR Slater
Mar 1, 1984·Journal of Speech and Hearing Research·R S Tyler, D Conrad-Armes
Jan 1, 1983·Audiology : Official Organ of the International Society of Audiology·C Mitchell
Mar 1, 1983·The Journal of the Acoustical Society of America·M Florentine, A J Houtsma
Mar 26, 1999·Trends in Neurosciences·J P Rauschecker
Jul 15, 2003·Otolaryngologic Clinics of North America·Jack A Vernon, Mary B Meikle
Oct 12, 2004·Trends in Neurosciences·Jos J Eggermont, Larry E Roberts
Jun 2, 2005·Trends in Neurosciences·Rodolfo LlinásHein J F van Marle
Jul 16, 2005·The Journal of the Acoustical Society of America·Martina Huss, Brian C J Moore
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Donald M CasparyLarry F Hughes
Dec 1, 2005·International Journal of Audiology·Martina Huss, Brian C J Moore
Nov 23, 2006·Acta Oto-laryngologica. Supplementum·Larry E RobertsDaniel J Bosnyak
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathan WeiszThomas Elbert
Mar 6, 2007·Nature Neuroscience·Scott J CruikshankBarry W Connors
Apr 25, 2007·Current Opinion in Neurobiology·Gina Turrigiano
Oct 25, 2007·Progress in Brain Research·Larry E Roberts
Jan 12, 2011·Neuron·Amber M LeaverJosef P Rauschecker

❮ Previous
Next ❯

Citations

Apr 6, 2012·Journal of the Association for Research in Otolaryngology : JARO·Derek J HoareDeborah A Hall
Apr 25, 2012·Journal of the Association for Research in Otolaryngology : JARO·Kelly M ReavisFan-Gang Zeng
Jul 14, 2012·Journal of the Association for Research in Otolaryngology : JARO·Peyman AdjamianAlan R Palmer
Sep 15, 2012·Brain : a Journal of Neurology·William SedleyTimothy David Griffiths
Dec 19, 2013·PloS One·Charles-Édouard BasileSylvie Hébert
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Larry E RobertsJames A Kaltenbach
Apr 11, 2013·Noise & Health·Karin M HeijnemanPim van Dijk
Feb 18, 2014·Hearing Research·Toshizo KoizumiHiroshi Hosoi
Jan 1, 2014·Hearing Research·Roland Schaette
Dec 4, 2014·International Journal of Audiology·Magdalena SeredaDeborah A Hall
Sep 4, 2015·International Journal of Audiology·Daniel DrexlerMarisa Pedemonte
Feb 13, 2016·Nature Reviews. Neurology·Susan E ShoreBerthold Langguth
Nov 28, 2012·American Journal of Otolaryngology·Stéphanie BertetOlivier Warusfel
Oct 24, 2012·Hearing Research·Arnaud J Noreña, Brandon J Farley
Sep 18, 2012·Brain Research·Anna Seydell-GreenwaldJosef P Rauschecker
Oct 12, 2011·Hearing Research·M-C EtchelecouA J Noreña
Dec 15, 2010·Hearing Research·James A Kaltenbach
Nov 26, 2010·Neuroscience and Biobehavioral Reviews·Arnaud Jean Noreña
Apr 15, 2009·Hearing Research·Peyman AdjamianDeborah A Hall
Sep 26, 2015·International Journal of Audiology·J JonssonG D Searchfield
Dec 15, 2015·BioMed Research International·Oliver Zobay, Peyman Adjamian
Sep 17, 2015·Nature Reviews. Neuroscience·Ana Belén ElgoyhenSven Vanneste
Jul 24, 2013·Neuroscience and Biobehavioral Reviews·Larry E RobertsJos J Eggermont
May 4, 2013·Hearing Research·Magdalena SeredaDeborah A Hall
Oct 1, 2014·Cell and Tissue Research·Jos J Eggermont, Larry E Roberts
Jun 16, 2015·Hearing Research·Calvin WuSusan E Shore
Sep 10, 2013·Hearing Research·Farhait KianiRoland Schaette
Apr 29, 2015·Current Biology : CB·William SedleyTimothy D Griffiths
Oct 24, 2014·Frontiers in Neurology·Laurence McKennaDeborah A Hall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved