PMID: 1194151Oct 1, 1975Paper

Residual levels and biochemical changes after ventilation with perfluorinated liquid

Journal of Applied Physiology
H W CalderwoodC I Hood

Abstract

Twenty-three beagle dogs were ventilated with perfluorinated liquid, perfluoro-1-isopropoxy-hexane (Caroxin-F) for 1 h and were reconverted to gaseous breathing. Hematologic and biochemical changes were studied in five dogs for 1 yr and the remaining animals were followed for evidence of retained Caroxin-F for up to 3 yr. We found that the dogs could be ventilated with liquid Caroxin-F and returned to spontaneous breathing of gaseous oxygen with normal blood gas exchange within 24-72 h. Serum alkaline phosphatase, serum cholesterol, and white blood cell count increased with liquid ventilation but returned to normal in less than 1 wk. Trace amounts of Caroxin-F were detected by chromatography in all tissues studied for the entire 3-yr period. The highest levels of Caroxin-F were found in the lungs and associated lymph nodes. No histologic evidence of the presence of Caroxin-F was seen except for local accumulations of vacuolated macrophages in the lungs and associated lymph nodes. We conclude that Caroxin-F can be breathed without residual deleterious effects, even though trace amounts remained for at least 3 yr.

Citations

Mar 26, 1998·Anaesthesia and Intensive Care·R C Leonard
Aug 26, 1998·Pediatric Pulmonology·M R WolfsonT H Shaffer
Apr 30, 1998·Annals of Medicine·C M WeisT H Shaffer
May 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Marla R WolfsonThomas H Shaffer
Nov 18, 2014·BJU International·Krishna RamaswamyMarshall Stoller
Sep 8, 2001·Critical Care Medicine·B NakstadT Lyberg
Feb 22, 2001·Journal of Applied Physiology·T F MillerM R Wolfson
Jan 1, 1996·Critical Care Medicine·J H Arnold
Dec 22, 1998·Pediatric Pulmonology·E M Bendel-StenzelM C Mammel
Apr 15, 1999·Current Opinion in Pediatrics·C M Weis, W W Fox

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