Residual low HDV viraemia is associated HDV RNA relapse after PEG-IFNa-based antiviral treatment of hepatitis delta: Results from the HIDIT-II study.

Liver International : Official Journal of the International Association for the Study of the Liver
Birgit BremerHeiner Wedemeyer

Abstract

The role of low levels of HDV-RNA during and after interferon therapy of hepatitis D is unknown. We re-analysed HDV RNA in 372 samples collected in the HIDIT-2 trial (Wedemeyer et al, Lancet Infectious Diseases 2019) with the Robogene assay (RA; Jena Analytics). Data were compared with the previously reported in-house assay (IA). We detected HDV-RNA in one-third of samples previously classified as undetectable using the highly sensitive RA. Low HDV viraemia detectable at week 48 or week 96 was associated with a high risk for post-treatment relapse, defined as HDV RNA positivity in both assays at week 120. HDV RNA relapses occurred in 10/15 (67%) patients with detectable low HDV RNA at week 48 and in 10/13 (77%) patients with low viraemia samples at week 96. In contrast, the post-treatment relapse rate was lower in patients with undetectable HDV RNA in both assays during treatment.

References

Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E M Brunt
Oct 21, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Kalliopi ZachouUNKNOWN HIDT-1 Study Group
Oct 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Johannes WiegandThomas Berg
Dec 18, 2012·Current Infectious Disease Reports·Benjamin HeidrichHeiner Wedemeyer
Dec 18, 2013·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Frédéric Le GalEmmanuel Gordien
Feb 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christie JoyaAnuradha Ganesan
Mar 6, 2019·The Lancet Infectious Diseases·Heiner WedemeyerUNKNOWN HIDIT-II study team

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Citations

Apr 4, 2021·Viruses·Katja Giersch, Maura Dandri

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