Residual malaria transmission dynamics varies across The Gambia despite high coverage of control interventions

PloS One
Julia MwesigwaUmberto D'Alessandro

Abstract

Over the last decades, malaria has declined substantially in The Gambia but its transmission has not been interrupted. In order to better target control interventions, it is essential to understand the dynamics of residual transmission. This prospective cohort study was conducted between June 2013 and April 2014 in six pairs of villages across The Gambia. Blood samples were collected monthly during the transmission season (June-December) from all residents aged ≥6 months (4,194 individuals) and then in April (dry season). Entomological data were collected monthly throughout the malaria transmission season. Ownership of Long-Lasting Insecticidal Nets was 71.5% (2766/3869). Incidence of malaria infection and clinical disease varied significantly across the country, with the highest values in eastern (1.7/PYAR) than in central (0.2 /PYAR) and western (0.1/PYAR) Gambia. Malaria infection at the beginning of the transmission season was significantly higher in individuals who slept outdoors (HR = 1.51, 95% CI: 1.02-2.23, p = 0.04) and in those who had travelled outside the village (HR = 2.47, 95% CI: 1.83-3.34, p <0.01). Sub-patent infections were more common in older children (HR = 1.35, 95% CI: 1.04-1.6, p <0.01) and adults (HR = 1...Continue Reading

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Citations

Oct 10, 2018·The American Journal of Tropical Medicine and Hygiene·Bryan GreenhouseChris J Drakeley
Oct 12, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julia MwesigwaUmberto D'Alessandro
Aug 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane AchanUmberto D'Alessandro
Jan 31, 2019·Malaria Journal·Emmanuel W KaindoaFredros O Okumu
Apr 28, 2021·The Journal of Infectious Diseases·Pierre Carnevale, Sylvie Manguin
May 13, 2021·Journal of the Royal Society, Interface·Ebrima JattaSteve W Lindsay

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Methods Mentioned

BETA
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electrophoresis

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Stata
QIAxcel

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