Residual psychomotor effects following reversal of midazolam sedation with flumazenil

Anaesthesia and Intensive Care
T G Short, D C Galletly

Abstract

The ability of flumazenil to reverse the effects of midazolam sedation was examined in a randomised, crossover, placebo controlled study in six male volunteers. Subjects received intravenous injections of either (a) midazolam 10 mg followed 10 minutes later by flumazenil 1.0 mg or (b) midazolam 10 mg followed after 10 minutes by flumazenil 4 mg or (c) placebo followed after 10 minutes by placebo. Post reversal drug effects were examined using a psychomotor battery (critical flicker fusion, digit symbol substitution, tapping test, ball-bearing test, number recall, reflex time) and linear analogue mood scales. It was found that a residual psychomotor deficit was present following flumazenil and that this persisted for up to 125 minutes after the 1.0 mg dose and 65 minutes following 4 mg. A small deterioration in performance was apparent after initial reversal with 1.0 mg, the peak deterioration occurring at 35 minutes.

References

Apr 1, 1987·British Journal of Anaesthesia·D J SageR A Boas
Nov 1, 1987·Anaesthesia and Intensive Care·P Forrest, D C Galletly
Aug 1, 1987·British Journal of Anaesthesia·D FaganD B Scott
Apr 1, 1983·British Journal of Anaesthesia·C O'BoyleM Kenny
May 1, 1965·British Journal of Anaesthesia·M D VICKERS

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Citations

Sep 1, 1995·Psychopharmacology·N J WesenstenG L Belenky
Jan 1, 1997·British Journal of Clinical Pharmacology·B H WilliamsonP J Thompson
Jun 26, 2002·Journal of Veterinary Pharmacology and Therapeutics·J E IlkiwE P Steffey

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