PMID: 3763830Jan 1, 1986Paper

Residual radiation effect in the murine hematopoietic stem cell compartment

Radiation and Environmental Biophysics
K H von WangenheimL E Feinendegen

Abstract

Stem cells surviving radiation injury may carry defects which contribute to long-term effects. The ratio of 125-iododeoxyuridine (IUdR) uptake into spleens of lethally irradiated recipient mice between day 3 and day 5 after cell transfusion revealed reduced proliferative ability (PF) of spleen seeding cells in parallel with reduced CFU-S content of donors throughout the study period of one year after 5 Gy gamma irradiation. Additional data aided in evaluating possible mechanisms of PF reduction. Within the range of the graft sizes used, PF was independent of the numbers of cells or CFU-S transfused. Radiation-induced increase in loss of label between days 3 and 5 and prolonged doubling time of proliferating cells indicated enhancement of cell maturation and increase in mitotic cycle time. Increased IUdR uptake per transfused CFU-S suggested extra divisions of transit cells due to insufficiency in the stem cell compartment. It is concluded that persisting defects in surviving stem cells interfere in a complex way with cell proliferation in the hemopoietic system.

References

Jul 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·H CroizatM Tubiana
Jan 1, 1985·Annals of the New York Academy of Sciences·K H WangenheimL E Feinendegen
Jan 1, 1985·Radiation and Environmental Biophysics·G E HübnerE P Cronkite
Jul 1, 1969·The Journal of Experimental Medicine·R G WortonJ E Till
Jun 3, 1967·Nature·E FrindelF Vassort
Nov 1, 1983·International Journal of Radiation Oncology, Biology, Physics·J H HendryN G Testa
Sep 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G P JoshiC A Shaw
Nov 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J E Coggle
Feb 11, 1982·Nature·M C MagliN Odartchenko

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Citations

Jan 1, 1985·Radiation and Environmental Biophysics·G E HübnerE P Cronkite
Oct 16, 2013·Antioxidants & Redox Signaling·Lijian ShaoDaohong Zhou
Jan 1, 1989·Radiation and Environmental Biophysics·H P PetersonL E Feinendegen
Jan 1, 1987·Radiation and Environmental Biophysics·K H von WangenheimL E Feinendegen
Jan 27, 2012·Radiation and Environmental Biophysics·Jiřina VávrováEmilie Lukášová

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