PMID: 11328277May 1, 2001Paper

Residual risk of transfusion in Ghana

British Journal of Haematology
Daniel CandottiJ-P Allain

Abstract

Plasma samples from replacement and volunteer blood donors in Kumasi, Ghana were pooled and tested using a duplex human immunodeficiency virus (HIV) and hepatitis C virus (HCV) RNA detection Individual plasmas constitutive of reactive pools were confirmed using reverse transcription-polymerase chain reaction. HIV and HCV infections were significantly higher in 1569 replacement donors than in 1169 volunteers; 2.4 and 1.7 versus 0.3 and 0.7% respectively (P < 0.01). Two duplex RNA-positive plasma pools contained a confirmed/seronegative HIV or HCV RNA individual plasma. The residual post-transfusion risk of HIV and HCV infection of blood collected from replacement blood donors ranged between 1:260 and 1:16 393 after screening for anti-HIV, p24 antigen and anti-HCV. These data indicate that in high-prevalence HIV and HCV blood donor populations, a substantial residual post-transfusion risk of infection remains. This risk might be reduced by collecting blood in younger volunteer donors or by genomic screening.

Citations

Jun 23, 2011·Bulletin de la Société de pathologie exotique·N HannachiJ Boukadida
May 4, 2004·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·A LouaM A Baldé
Apr 18, 2006·Critical Care Medicine·Caveh MadjdpourRichard B Weiskopf
Dec 24, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Claude Tayou TagnyUNKNOWN Recherches Transfusionnelles en Afrique Francophone
Jun 17, 2014·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J M KabindaS Y Ramazani
Feb 23, 2007·Tropical Medicine & International Health : TM & IH·Lena NovackBatia Sarov
Aug 21, 2008·Transfusion·Claude Tayou TagnyJean-Jacques Lefrère
Dec 6, 2008·Transfusion·Jean-Pierre Allain, Shirley Owusu-Ofori
Dec 24, 2005·Transfusion·Reem AmeenAbdulaziz Al-Bashir
Jul 7, 2012·Vox Sanguinis·H F BuggeP M Jourdan
May 5, 2011·British Journal of Haematology·Jean-Pierre Allain
Oct 22, 2009·Transfusion·Sudha JayaramanIan Roberts
Jul 11, 2006·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·H OuattaraS Abissey
Mar 8, 2016·Tropical Medicine & International Health : TM & IH·Cara S Kosack, Sigrid Nick
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Marinus van HulstMaarten J Postma
Aug 11, 2016·BMC Infectious Diseases·Akosua Adom AgyemanGeorge Ashiagbor
May 4, 2004·Journal of Medical Virology·Lucia FischettiJean Pierre Allain
Mar 23, 2006·Current Opinion in Anaesthesiology·Danja Strumper-Groves
Feb 23, 2007·Journal of Medical Microbiology·Andrew A AdjeiGeorge Mensah
May 23, 2014·Transfusion·Ohene Opare-SemShirley Owusu-Ofori

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