Residual serum monoclonal protein predicts progression-free survival in patients with previously untreated multiple myeloma.

Cancer
Eric W SchaeferSumithra J Mandrekar

Abstract

Currently used treatment response criteria in multiple myeloma (MM) are based in part on serum monoclonal protein (M-protein) measurements. A drawback of these criteria is that response is determined solely by the best level of M-protein reduction, without considering the serial trend. The authors hypothesized that metrics incorporating the serial trend of M-protein would be better predictors of progression-free survival (PFS). Fifty-five patients with measurable disease at baseline (M-protein > or = 1 g/dL) who received > or = 4 cycles of treatment from 2 clinical trials in previously untreated MM were included. Three metrics based on the percentage of M-protein remaining relative to baseline (residual M-protein) were considered: metrics based on the number of times residual M-protein fell within prespecified thresholds, metrics based on area under the residual M-protein curve, and metrics based on the average residual M-protein reduction between Cycles 1 and 4. The predictive value of these metrics was assessed in Cox models using landmark analysis. The average residual M-protein reduction was found to be significantly predictive of PFS (P = .02; hazard ratio, 0.37), in which a patient with a 10% lower average residual M-prot...Continue Reading

References

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Jul 21, 2006·Leukemia·B G M DurieUNKNOWN International Myeloma Working Group

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Citations

Oct 12, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Takuro YamamotoJo Kitawaki
Dec 1, 2011·Epigenomics·Cristina FloreanMarc Diederich
Mar 17, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·S VenkateshA K Grover

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