Residual tumour in the marginal resection after a complete transurethral resection is associated with local recurrence in Ta/T1 urinary bladder cancer

Scandinavian Journal of Urology and Nephrology
Georg JanckeStaffan Jahnson

Abstract

This study investigated the presence of residual tumour in the marginal resection (MR) after a complete transurethral resection (TURB) of Ta/T1 transitional urinary bladder cancer. The association between positive MR and recurrence was analysed. After macroscopically complete TURB, a marginal resection of 7 mm (corresponding to the diameter of the resection loop) was removed around the entire resection area. Univariate and multivariate Cox regression analyses were performed to assess the influence of residual disease on recurrence. In all, 94 patients with a median follow-up time of 36 months were included, and residual tumour in the MR was present in 24 (26%). The recurrence rates for all cases, for those with a tumour-positive and a tumour-free MR were 60 (64%), 20 (83%) and 40 (57%), respectively. Local recurrence was found in 14 (58%) of the patients with tumour presence in the MR compared to 13 (19%) of those with a tumour-free margin. A positive MR was significantly associated with overall recurrence (p < 0.001) and local recurrence (p = 0.001). Incomplete transurethral resection of bladder cancer is common, as demonstrated in 26% patients with positive MR. The presence of tumour in the MR may be a risk factor for recurre...Continue Reading

References

Aug 1, 1986·The Journal of Urology·D PodeS Biran
Nov 7, 2001·The Journal of Urology·S Saito
May 13, 2008·European Urology·Marko BabjukUNKNOWN European Association of Urology (EAU)
Jul 9, 2008·Scandinavian Journal of Urology and Nephrology·G JanckeS Jahnson
Nov 28, 2008·BJU International·Harry W Herr, S Machele Donat
Mar 5, 2009·World Journal of Urology·Daniel WilbyTimothy O'Brien
Jun 18, 2011·Scandinavian Journal of Urology and Nephrology·Georg JanckeStaffan Jahnson

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