Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

doi:10.1039/c9sc00531e

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Chemical Science

Jul 14, 2019

Susmitha AmbadipudiMarkus Zweckstetter

PMID: 31341602

DOI: 10.1039/c9sc00531e

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Abstract

Liquid-liquid phase separation (LLPS) of proteins enables the formation of non-membrane-bound organelles in cells and is associated with cancer and neurodegeneration. Little is known however about the structure and dynamics of proteins in LLPS conditions, because of the polymorphic natu...read more

Mentioned in this Paper

Malignant Neoplasms

Nerve Degeneration

Hexamethylene glycol

Tau Proteins

Chemicals

Liquid Diet

Structure

Gene Polymorphism

Research Study

Spectroscopy, Nuclear Magnetic Resonance

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