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Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Chemical Science

Jul 14, 2019

Susmitha AmbadipudiMarkus Zweckstetter

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Abstract

Liquid-liquid phase separation (LLPS) of proteins enables the formation of non-membrane-bound organelles in cells and is associated with cancer and neurodegeneration. Little is known however about the structure and dynamics of proteins in LLPS conditions, because of the polymorphic natu...read more

Mentioned in this Paper

Malignant Neoplasms
Nerve Degeneration
Hexamethylene glycol
Tau Proteins
Chemicals
Liquid Diet
Structure
Gene Polymorphism
Research Study
Spectroscopy, Nuclear Magnetic Resonance
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18
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Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Chemical Science

Jul 14, 2019

Susmitha AmbadipudiMarkus Zweckstetter

PMID: 31341602

DOI: 10.1039/c9sc00531e

Abstract

Liquid-liquid phase separation (LLPS) of proteins enables the formation of non-membrane-bound organelles in cells and is associated with cancer and neurodegeneration. Little is known however about the structure and dynamics of proteins in LLPS conditions, because of the polymorphic natu...read more

Mentioned in this Paper

Malignant Neoplasms
Nerve Degeneration
Hexamethylene glycol
Tau Proteins
Chemicals
1
18

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