Jul 10, 2020

Resilience in the LPS-induced acute depressive-like behaviors: Increase of CRMP2 neuroprotection and microtubule dynamics in hippocampus

Brain Research Bulletin
Zuotian WuLimin Sun


Depressive-like behaviors occur at 24 h after lipopolysaccharide (LPS) injection, but whether the animals have resilience has not been reported. This study is to explore the existence of resilience in the LPS-induced acute depressive-like behaviors and its biological changes in the neuroprotection and microtubule dynamics. The behavioral tests of Sprague-Dawley male rats, including body weight (BW), sucrose preference test (SPT), forced swimming test (FST) and open field test (OFT), which are used to explore depressive and anxiety-like behaviors, were detected at 24 h after intraperitoneal injection of LPS. In the LPS-induced depression group, body weight and sucrose preference index in SPT were decreased, the immobility time in FST was increased, total distance, time in central zone and frequency of rearing in OFT were decreased. However, there was not any difference in behavioral phenotypes between the resilient animals and the saline control group. The activity of collapsing response mediator protein 2 (CRMP2), which is related to neuronal plasticity and neuroprotection, was increased in resilient rats. The brain-derived neurotrophic factor (BDNF) mRNA expression was also increased. The ratio of Tyr/Acet-tubulin in hippocamp...Continue Reading

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Mentioned in this Paper

Structure of Dentate Gyrus
Central Zone of Nerve
BDNF gene
Detected (Finding)
Regulation of Microtubule Cytoskeleton Organization
Behavioral Test
Hippocampus (Brain)
Protein Expression

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