Abstract
Early life adversity (ELA) increases major depressive disorder (MDD) and suicide risk and potentially affects dentate gyrus (DG) plasticity. We reported smaller DG and fewer granular neurons (GNs) in MDD. ELA effects on DG plasticity in suicide decedents with MDD (MDDSui) and resilient subjects (ELA history without MDD or suicide) are unknown. We quantified neural progenitor cells (NPCs), GNs, glia, and DG volume in whole hippocampus postmortem in four groups of drug-free, neuropathology-free subjects (N = 52 total): psychological autopsy-defined MDDSui and control subjects with and without ELA (before 15 years of age). ELA was associated with larger DG (p < .0001) and trending fewer NPCs (p = .0190) only in control subjects in whole DG, showing no effect on NPCs and DG volume in MDDSui. ELA exposure was associated with more GNs (p = .0003) and a trend for more glia (p = .0160) in whole DG in MDDSui and control subjects. MDDSui without ELA had fewer anterior and mid DG GNs (p < .0001), fewer anterior DG NPCs (p < .0001), and smaller whole DG volume (p = .0005) compared with control subjects without ELA. In MDDSui, lower Global Assessment Scale score correlated with fewer GNs and smaller DG. Resilience to ELA involves a larger D...Continue Reading
Citations
Jun 5, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Viktoria Kheifets, Steven P Braithwaite
Jul 30, 2020·Stem Cells and Development·Rui S RodriguesSara Xapelli
Oct 2, 2020·The American Journal of Psychiatry·J John Mann, Mina M Rizk
Apr 10, 2020·Neuronal Signaling·Paul J LucassenMirjana Maletic-Savatic
Jul 9, 2020·Neuromolecular Medicine·Moshe HagarSredni Benjamin
Aug 3, 2019·Surgical and Radiologic Anatomy : SRA·Robert Haładaj
Aug 29, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Milenna T van DijkArdesheer Talati
Aug 2, 2019·Behavioural Brain Research·Xin LiangYong Tang
Mar 10, 2020·The European Journal of Neuroscience·Romain TroubatVincent Camus
Jan 14, 2020·Neuroscience·Demelza M SmeethSandrine Thuret
Nov 14, 2020·Biological Psychiatry·Dong SunWen-Cheng Xiong
Feb 10, 2021·International Journal of Molecular Sciences·Pietro Cacialli
Feb 6, 2021·Brain Communications·Ksenia MusaelyanSandrine Thuret
May 19, 2020·Trends in Molecular Medicine·Thomas BergerSandrine Thuret
Mar 27, 2021·JAMA Psychiatry·Maura BoldriniRobyn S Klein
May 14, 2021·Neural Plasticity·Idriss Ali AbdoulayeYi-Jing Guo
May 16, 2021·Molecular Psychiatry·Anthony CarrardJean-Luc Martin
Jul 19, 2021·Biological Psychiatry·Olga Therese OusdalLeif Oltedal
Jul 25, 2021·International Journal of Molecular Sciences·Julia LeschikAntonietta Gentile
Aug 6, 2021·Brain, Behavior, and Immunity·Amalie C M CouchAnthony C Vernon
Aug 14, 2021·Drug Design, Development and Therapy·Shan ZhangLi Li
Sep 3, 2021·Translational Psychiatry·Rebecca B PriceMary Woody