Resin glycosides from Ipomoea wolcottiana as modulators of the multidrug resistance phenotype in vitro

Phytochemistry
Berenice Corona-CastañedaRogelio Pereda-Miranda

Abstract

Recycling liquid chromatography was used for the isolation and purification of resin glycosides from the CHCl3-soluble extracts prepared using flowers of Ipomoea wolcottiana Rose var. wolcottiana. Bioassay-guided fractionation, using modulation of both antibiotic activity against multidrug-resistant strains of Gram-negative bacteria and vinblastine susceptibility in breast carcinoma cells, was used to isolate the active glycolipids as modulators of the multidrug resistance phenotype. An ester-type dimer, wolcottine I, one tetra- and three pentasaccharides, wolcottinosides I-IV, in addition to the known intrapilosin VII, were characterized by NMR spectroscopy and mass spectrometry. In vitro assays established that none of these metabolites displayed antibacterial activity (MIC>512 μg/mL) against multidrug-resistant strains of Escherichia coli, and two nosocomial pathogens: Salmonella enterica serovar Typhi and Shigella flexneri; however, when tested (25 μg/mL) in combination with tetracycline, kanamycin or chloramphenicol, they exerted a potentiation effect of the antibiotic susceptibility up to eightfold (64 μg/mL from 512 μg/mL). It was also determined that these non-cytotoxic (CI50>8.68 μM) agents modulated vinblastine suscep...Continue Reading

References

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Apr 29, 2006·Journal of Natural Products·Lilia Chérigo, Rogelio Pereda-Miranda
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Apr 2, 2011·Phytochemistry·Daniel Rosas-RamírezRogelio Pereda-Miranda
Oct 18, 2011·Planta medica·Berenice Corona-Castañeda, Rogelio Pereda-Miranda
Dec 14, 2011·Journal of Natural Products·Gabriela Figueroa-GonzálezRogelio Pereda-Miranda
Aug 29, 2012·Journal of Natural Products·Sara Cruz-MoralesRogelio Pereda-Miranda
Jan 1, 2013·Journal of Natural Products·Jhon Castañeda-GómezRogelio Pereda-Miranda
Aug 8, 2013·Phytochemistry·Berenice Corona-CastañedaRogelio Pereda-Miranda
Sep 24, 2013·Journal of Agricultural and Food Chemistry·Daniel Rosas-Ramírez, Rogelio Pereda-Miranda
Dec 23, 2014·Journal of Natural Products·Daniel Rosas-Ramírez, Rogelio Pereda-Miranda

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Citations

Feb 27, 2018·Journal of Medicinal Food·Lilian Dolores Chel-GuerreroJosé Alberto Mendoza-Espinoza
Jul 28, 2017·Journal of Natural Medicines·Masateru Ono
Jun 13, 2019·Journal of Natural Products·Jesús Lira-RicárdezSuzana Guimarães Leitão
Nov 25, 2021·Natural Product Research·Masateru OnoToshihiro Nohara

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